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[Fetal exposure to bisphenol A: Presence of bisphenol A in urine of pregnant women assisted in a hospital in the City of Buenos Aires. Year 2013].[胎儿暴露于双酚A：布宜诺斯艾利斯市一家医院收治的孕妇尿液中双酚A的存在情况。2013年]
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Bisphenol A in Urine of Chinese Young Adults: Concentrations and Sources of Exposure.中国年轻人尿液中的双酚A：浓度及暴露源
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Direct measurement of Bisphenol A (BPA), BPA glucuronide and BPA sulfate in a diverse and low-income population of pregnant women reveals high exposure, with potential implications for previous exposure estimates: a cross-sectional study.对不同收入水平的孕妇群体直接测量双酚A（BPA）、BPA葡萄糖醛酸苷和BPA硫酸盐，结果显示暴露水平较高，这对先前的暴露估计可能有影响：一项横断面研究。
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A possible approach to improving the reproducibility of urinary concentrations of phthalate metabolites and phenols during pregnancy.一种提高孕期尿中邻苯二甲酸代谢物和酚类浓度重现性的可能方法。
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Within-Day, Between-Day, and Between-Week Variability of Urinary Concentrations of Phenol Biomarkers in Pregnant Women.孕妇尿液中酚类生物标志物日内、日间和周间变异性。
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Distribution, variability, and predictors of urinary bisphenol A levels in 50 North Carolina adults over a six-week monitoring period.50 名北卡罗来纳州成年人在六周监测期间尿液双酚 A 水平的分布、变异性和预测因素。
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本文引用的文献

1
The concentration of bisphenol A in urine is affected by specimen collection, a preservative, and handling.尿液中双酚 A 的浓度受标本采集、防腐剂和处理的影响。
Environ Res. 2013 Oct;126:211-4. doi: 10.1016/j.envres.2013.07.002. Epub 2013 Jul 27.
2
Dietary and sociodemographic determinants of bisphenol A urine concentrations in pregnant women and children.孕妇和儿童尿液中双酚 A 浓度的饮食和社会人口统计学决定因素。
Environ Int. 2013 Jun;56:10-8. doi: 10.1016/j.envint.2013.02.014. Epub 2013 Mar 26.
3
Potential external contamination with bisphenol A and other ubiquitous organic environmental chemicals during biomonitoring analysis: an elusive laboratory challenge.在生物监测分析中，双酚 A 和其他普遍存在的有机环境化学物质可能存在潜在的外部污染：一个难以捉摸的实验室挑战。
Environ Health Perspect. 2013 Mar;121(3):283-6. doi: 10.1289/ehp.1206093. Epub 2013 Jan 16.
4
Bisphenol A in 24 h urine and plasma samples of the German Environmental Specimen Bank from 1995 to 2009: a retrospective exposure evaluation.2009 年，德国环境生物库 1995 年至 2009 年期间的 24 小时尿液和血浆样本中的双酚 A：回顾性暴露评估。
J Expo Sci Environ Epidemiol. 2012 Nov;22(6):610-6. doi: 10.1038/jes.2012.39. Epub 2012 May 23.
5
Prenatal bisphenol a exposure and child behavior in an inner-city cohort.产前双酚 A 暴露与城市内城区队列儿童行为。
Environ Health Perspect. 2012 Aug;120(8):1190-4. doi: 10.1289/ehp.1104492. Epub 2012 Apr 27.
6
Variability of urinary phthalate metabolite and bisphenol A concentrations before and during pregnancy.孕期前后尿邻苯二甲酸代谢物和双酚 A 浓度的变异性。
Environ Health Perspect. 2012 May;120(5):739-45. doi: 10.1289/ehp.1104139. Epub 2012 Jan 19.
7
Impact of early-life bisphenol A exposure on behavior and executive function in children.双酚 A 暴露对儿童行为和执行功能的影响。
Pediatrics. 2011 Nov;128(5):873-82. doi: 10.1542/peds.2011-1335. Epub 2011 Oct 24.
8
Bisphenol A and children's health.双酚 A 与儿童健康。
Curr Opin Pediatr. 2011 Apr;23(2):233-9. doi: 10.1097/MOP.0b013e3283445675.
9
Variability and predictors of urinary bisphenol A concentrations during pregnancy.孕期尿液双酚 A 浓度的变异性及其预测因素。
Environ Health Perspect. 2011 Jan;119(1):131-7. doi: 10.1289/ehp.1002366.
10
Renal function, bisphenol A, and alkylphenols: results from the National Health and Nutrition Examination Survey (NHANES 2003-2006).肾功能、双酚 A 和烷基酚：来自国家健康和营养检查调查（NHANES 2003-2006）的结果。
Environ Health Perspect. 2011 Apr;119(4):527-33. doi: 10.1289/ehp.1002572. Epub 2010 Dec 8.

“R世代研究”中孕期尿双酚A浓度测量的可重复性。

Reproducibility of urinary bisphenol A concentrations measured during pregnancy in the Generation R Study.

作者信息

Jusko Todd A, Shaw Pamela A, Snijder Claudia A, Pierik Frank H, Koch Holger M, Hauser Russ, Jaddoe Vincent W V, Burdorf Alex, Hofman Albert, Tiemeier Henning, Longnecker Matthew P

机构信息

Department of Public Health Sciences, University of Rochester School of Medicine and Dentistry, 265 Crittenden Boulevard, Rochester, New York, USA.

Department of Biostatistics and Epidemiology, University of Pennsylvania Perelman School of Medicine, 423 Guardian Drive, Philadelphia, Pennsylvania, USA.

出版信息

J Expo Sci Environ Epidemiol. 2014 Sep-Oct;24(5):532-6. doi: 10.1038/jes.2014.23. Epub 2014 Apr 16.

DOI:10.1038/jes.2014.23
PMID:24736100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4140995/
Abstract

The potential human health effects of bisphenol A (BPA) exposure are a public health concern. In order to design adequately powered epidemiological studies to address potential health effects, data on the reproducibility of BPA concentration in serial urine specimens taken during pregnancy are needed. To provide additional data on the reproducibility of maternal urine specimens, 80 women in the Generation R Study (Rotterdam, The Netherlands) contributed a spot urine specimen at <18, 18-25, and >25 weeks of pregnancy. Reproducibility, estimated by the intraclass correlation coefficient (ICC), was 0.32 (95% confidence interval: 0.18-0.46), and, on a creatinine basis, 0.31 (95% confidence interval: 0.16-0.47). Although the ICC observed in the Generation R Study is slightly higher than previous reproducibility studies of BPA, it nevertheless indicates a high degree of within-person variability that presents challenges for designing well-powered epidemiologic studies.

摘要

双酚A（BPA）暴露对人类健康的潜在影响是一个公共卫生问题。为了设计出有足够效力的流行病学研究来探讨潜在的健康影响，需要有关孕期采集的系列尿液标本中BPA浓度可重复性的数据。为了提供更多关于孕妇尿液标本可重复性的数据，代际R研究（荷兰鹿特丹）中的80名女性在孕期<18周、18 - 25周和>25周时分别提供了一份随机尿液标本。通过组内相关系数（ICC）估计的可重复性为0.32（95%置信区间：0.18 - 0.46），以肌酐为基础时为0.31（95%置信区间：0.16 - 0.47）。尽管在代际R研究中观察到的ICC略高于先前关于BPA的可重复性研究，但它仍表明个体内部存在高度变异性，这给设计有足够效力的流行病学研究带来了挑战。