Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA; Biomedical Sciences, University of Missouri, Columbia, MO 65211, USA; Thompson Center for Autism and Neurobehavioral Disorders, University of Missouri, Columbia, MO 65211, USA; Genetics Area Program, University of Missouri, Columbia, MO 65211, USA.
Front Neuroendocrinol. 2017 Oct;47:123-133. doi: 10.1016/j.yfrne.2017.08.001. Epub 2017 Aug 8.
Animal and human studies provide evidence that exposure to the endocrine disrupting chemical (EDC), bisphenol A (BPA), can lead to neurobehavioral disorders. Consequently, there is an impetus to identify safer alternatives to BPA. Three bisphenol compounds proposed as potential safer alternatives to BPA are bisphenol S (BPS), bisphenol F (BPF), and bisphenol AF (BPAF). However, it is not clear whether these other compounds are safer in terms of inducing less endocrine disrupting effects in animals and humans who are now increasingly coming into contact with these BPA-substitutes. In the past few years, several animal studies have shown exposure to these other bisphenols induce similar neurobehavioral disruption as BPA. We will explore in this review article the current studies suggesting these other bisphenols result in neuroendocrine disruptions that may be estrogen receptor-dependent. Current work may aide in designing future studies to test further whether these BPA-substitutes can act as neuroendocrine disruptors.
动物和人体研究都证明，暴露于内分泌干扰化学物质（EDC）双酚 A（BPA）会导致神经行为障碍。因此，人们迫切需要寻找更安全的 BPA 替代品。有三种双酚化合物被提议作为 BPA 的潜在更安全替代品，分别是双酚 S（BPS）、双酚 F（BPF）和双酚 AF（BPAF）。然而，目前还不清楚这些其他化合物在动物和人类中是否更安全，因为动物和人类现在越来越多地接触到这些 BPA 替代品，这些替代品引发的内分泌干扰作用更小。在过去的几年中，有几项动物研究表明，接触这些其他双酚类物质会导致与 BPA 类似的神经行为障碍。在这篇综述文章中，我们将探讨目前的研究表明这些其他双酚类物质会导致神经内分泌紊乱，这种紊乱可能依赖于雌激素受体。目前的研究工作可能有助于设计未来的研究，以进一步测试这些 BPA 替代品是否可以作为神经内分泌干扰物。
