Khayatzadeh Saeid, Feizi Awat, Saneei Parvane, Esmaillzadeh Ahmad
Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.
J Res Med Sci. 2015 Aug;20(8):790-6. doi: 10.4103/1735-1995.168404.
We are aware of no systematic review or meta-analysis of published findings about the association between Vitamin D status and risk of gastric cancer (GC). We systematically reviewed the current evidence on the association between Vitamin D intake as well as serum 25-hydroxy Vitamin D (25(OH)D) levels and risk of GC.
Published evidence in this area was searched to August 2014 through the use of ISI Web of Science, Scopus, PubMed/Medline, Ovid Database, EMBASE, and Google Scholar for relevant articles by cross-referencing. Seven articles had reported odds ratios (ORs) or relative risks (RR) as their effect size; four papers had reported the ORs between Vitamin D intake and GC; and three papers had reported the association between serum 25(OH)D and risk of GC.
Pooled effect size for comparison of highest versus lowest intakes of Vitamin D was 1.09 (95% confidence interval [CI]: 0.94, 1.25; P = 0.26) indicating no significant association between Vitamin D intake and risk of GC. We failed to find a significant association between serum Vitamin D levels and risk of GC (OR: 0.92; 95% CI: 0.74-1.14; P = 0.429). Among men, the pooled effect size or highest versus lowest category of serum Vitamin D levels was 0.92 (95% CI: 0.71, 1.18, P = 0.49). The corresponding figures in women were 1.04 and 95% CI: 0.74-1.47 (P = 0.80).
We found no evidence for the significant association between Vitamin D status and risk of GC. However, due to limited data in this field, further studies are required to reach a definite conclusion.
我们知晓尚无关于维生素D状态与胃癌（GC）风险之间关联的已发表研究结果的系统评价或荟萃分析。我们系统地回顾了当前关于维生素D摄入量以及血清25-羟基维生素D（25(OH)D）水平与GC风险之间关联的证据。
通过使用ISI Web of Science、Scopus、PubMed/Medline、Ovid数据库、EMBASE和谷歌学术，交叉引用相关文章，检索截至2014年8月该领域已发表的证据。七篇文章报告了比值比（OR）或相对风险（RR）作为其效应量；四篇论文报告了维生素D摄入量与GC之间的OR；三篇论文报告了血清25(OH)D与GC风险之间的关联。
维生素D最高摄入量与最低摄入量比较的合并效应量为1.09（95%置信区间[CI]：0.94，1.25；P = 0.26），表明维生素D摄入量与GC风险之间无显著关联。我们未发现血清维生素D水平与GC风险之间存在显著关联（OR：0.92；95% CI：0.74 - 1.14；P = 0.429）。在男性中，血清维生素D水平最高类别与最低类别比较的合并效应量为0.92（95% CI：0.71，1.18，P = 0.49）。女性中的相应数字为1.04和95% CI：0.74 - 1.47（P = 0.80）。
我们未发现维生素D状态与GC风险之间存在显著关联的证据。然而，由于该领域数据有限，需要进一步研究以得出明确结论。
