自闭症谱系障碍领域的锌/铜水平：一项系统评价与荟萃分析。

Zn/Cu Levels in the Field of Autism Disorders: A Systematic Review and Meta-analysis.

作者信息

Sayehmiri Fatemeh, Babaknejad Nasim, Bahrami Somayeh, Sayehmiri Kourosh, Darabi Mojtaba, Rezaei-Tavirani Mostafa

机构信息

Biochemistrist, Ilam University of Medical Sciences Research Committee, Ilam, Iran.

Department of Biostatistics, Department of Social Medicine, School of Medicine, University of Ilam, Ilam, Iran.

出版信息

Iran J Child Neurol. 2015 Fall;9(4):1-9.

OBJECTIVE

There is probably a relationship between zinc/cupper concentration in individuals with autism. The present review was written to estimate this probability by using meta-analysis method.

MARTIALS & METHODS: In this meta-analysis of Fixed Effect Model, by searching PubMed, Scopus and Google scholar databases, 11 articles were selected and verified published in 1978 to 2012. I² statistics were calculated to examine heterogeneity. The information was analyzed by R and STATA Ver. 11.2.

RESULTS

Due to non-uniform measurement methods of Zn/Cu concentrations, the concentration of these elements was measured in various subgroups (plasma, hair and general) in both study cases and controls. There was a significant statistical difference between plasma OR=0.252 (95% CI: -0.001-0.504) and hair OR=0.27(95% CI: 0.059-0.481, P=0.01) concentrations of Zn/Cu statuses between controls and autistic patients. Using a Fixed Effects Model, the overall integration of data from the two groups was significant as risk factor OR=0.31(95% CI:0.16-0.46, P=0.001).

CONCLUSION

Significant correlation existed between Zn/Cu levels and the development of autistic disorders in general analysis. Therefore, Zn/Cu levels could be mentioned as a pathogenesis reason of autism spectrum disorders.

目的

自闭症患者体内锌/铜浓度之间可能存在关联。本综述旨在通过荟萃分析方法评估这种可能性。

材料与方法

在本次固定效应模型的荟萃分析中，通过检索PubMed、Scopus和谷歌学术数据库，选取了11篇于1978年至2012年发表并经核实的文章。计算I²统计量以检验异质性。使用R和STATA 11.2版本对信息进行分析。

结果

由于锌/铜浓度的测量方法不统一，在研究病例组和对照组的各个亚组（血浆、头发和总体）中均对这些元素的浓度进行了测量。对照组与自闭症患者之间，血浆中锌/铜状态的OR值为0.252（95%置信区间：-0.001 - 0.504），头发中锌/铜状态的OR值为0.27（95%置信区间：0.059 - 0.481，P = 0.01），存在显著的统计学差异。采用固定效应模型，两组数据的总体合并作为危险因素具有显著性，OR值为0.31（95%置信区间：0.16 - 0.46，P = 0.001）。