Department of Animal and Food Sciences, University of Delaware , Newark, DE , USA.
United States Department of Agriculture, Agricultural Research Service, Southern Plains Agricultural Research Center , College Station, TX , USA.
Front Vet Sci. 2015 Oct 13;2:44. doi: 10.3389/fvets.2015.00044. eCollection 2015.
Immunometabolism is a relatively new research perspective, focusing on both metabolism and immunology and the cross-talk between these biological processes. Immunometabolism can be considered from two perspectives; 1) the role that immune cells play in organ metabolism and metabolic disease, and 2) the metabolic processes that occur within immune cells and how they affect overall immunity. The gut may be the prototypical organ of immunometabolism. The gut is the site of nutrient absorption and is a major, if not the major, immune organ. We also describe the integration of kinomics and the species-specific peptide array to the study of the gut. This unique immunometabolic tool combined with the unique immunometabolic nature of the gut provides significant research potential to many animal health applications.
免疫代谢是一个相对较新的研究视角，专注于代谢和免疫学以及这些生物过程之间的交流。可以从两个角度考虑免疫代谢；1）免疫细胞在器官代谢和代谢疾病中的作用，以及 2）免疫细胞内发生的代谢过程以及它们如何影响整体免疫。肠道可能是免疫代谢的典型器官。肠道是营养吸收的部位，是主要的（如果不是主要的）免疫器官。我们还描述了将激酶组学和种特异性肽阵列整合到肠道研究中的情况。这种独特的免疫代谢工具结合肠道独特的免疫代谢性质，为许多动物健康应用提供了巨大的研究潜力。
