外泌体：基础生物学及其在心血管生理学中的作用
Exosomes: Fundamental Biology and Roles in Cardiovascular Physiology.
作者信息
Ibrahim Ahmed, Marbán Eduardo
机构信息
Capricor, Los Angeles, California 90211.
Cedars-Sinai Heart Institute, Los Angeles, California 90048; email:
出版信息
Annu Rev Physiol. 2016;78:67-83. doi: 10.1146/annurev-physiol-021115-104929. Epub 2015 Nov 30.
Abstract
Exosomes are nanosized membrane particles that are secreted by cells that transmit information from cell to cell. The information within exosomes prominently includes their protein and RNA payloads. Exosomal microRNAs in particular can potently and fundamentally alter the transcriptome of recipient cells. Here we summarize what is known about exosome biogenesis, content, and transmission, with a focus on cardiovascular physiology and pathophysiology. We also highlight some of the questions currently under active investigation regarding these extracellular membrane vesicles and their potential in diagnostic and therapeutic applications.
摘要
外泌体是由细胞分泌的纳米级膜性颗粒，能够在细胞间传递信息。外泌体内的信息主要包括其携带的蛋白质和RNA。特别是外泌体中的微小RNA能够有力且从根本上改变受体细胞的转录组。在此，我们总结了关于外泌体生物发生、内容物和传递的已知信息，重点关注心血管生理学和病理生理学。我们还强调了目前关于这些细胞外膜泡及其在诊断和治疗应用中的潜力正在积极研究的一些问题。
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