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Preserved effector functions of human ORAI1- and STIM1-deficient neutrophils.

作者信息

Elling Roland, Keller Baerbel, Weidinger Carl, Häffner Monika, Deshmukh Sachin D, Zee Isabelle, Speckmann Carsten, Ehl Stephan, Schwarz Klaus, Feske Stefan, Henneke Philipp

机构信息

Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Mass.

Center for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany.

出版信息

J Allergy Clin Immunol. 2016 May;137(5):1587-1591.e7. doi: 10.1016/j.jaci.2015.09.047. Epub 2015 Dec 6.

DOI:10.1016/j.jaci.2015.09.047
PMID:26670474
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4860117/
Abstract
摘要

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本文引用的文献

1
Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation.免疫缺陷患者中的错义突变显示了卷曲螺旋结构域3（CC3）在STIM1激活中的多功能作用。
Proc Natl Acad Sci U S A. 2015 May 12;112(19):6206-11. doi: 10.1073/pnas.1418852112. Epub 2015 Apr 27.
2
Store-operated calcium signaling in neutrophils.中性粒细胞中的储存式钙信号传导
J Leukoc Biol. 2015 Oct;98(4):497-502. doi: 10.1189/jlb.2MR1114-573R. Epub 2015 Feb 24.
3
A cell-based systems biology assessment of human blood to monitor immune responses after influenza vaccination.一种基于细胞的系统生物学方法评估人体血液，以监测流感疫苗接种后的免疫反应。
PLoS One. 2015 Feb 23;10(2):e0118528. doi: 10.1371/journal.pone.0118528. eCollection 2015.
4
STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense.STIM1 钙传感器在炎症和宿主防御期间被激活吞噬细胞氧化酶所必需。
Blood. 2014 Apr 3;123(14):2238-49. doi: 10.1182/blood-2012-08-450403. Epub 2014 Feb 3.
5
Insulin modulates the inflammatory granulocyte response to streptococci via phosphatidylinositol 3-kinase.胰岛素通过磷脂酰肌醇 3-激酶调节对链球菌的炎症粒细胞反应。
J Immunol. 2012 Nov 1;189(9):4582-91. doi: 10.4049/jimmunol.1200205. Epub 2012 Sep 26.
6
Immunodeficiency due to defects in store-operated calcium entry.由于储存操纵钙内流缺陷导致的免疫缺陷。
Ann N Y Acad Sci. 2011 Nov;1238:74-90. doi: 10.1111/j.1749-6632.2011.06240.x.
7
Pharmacology of receptor operated calcium entry in human neutrophils.人中性粒细胞受体操纵性钙内流的药理学。
Int Immunopharmacol. 2011 Feb;11(2):145-8. doi: 10.1016/j.intimp.2010.11.006. Epub 2010 Nov 20.
8
STIM1 but not STIM2 is an essential regulator of Ca2+ influx-mediated NADPH oxidase activity in neutrophil-like HL-60 cells.在类中性粒细胞HL-60细胞中，基质相互作用分子1（STIM1）而非基质相互作用分子2（STIM2）是Ca2+内流介导的NADPH氧化酶活性的关键调节因子。
Biochem Pharmacol. 2009 Sep 1;78(5):504-13. doi: 10.1016/j.bcp.2009.05.006. Epub 2009 May 9.
9
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function.Orai1基因的突变通过消除CRAC通道功能导致免疫缺陷。
Nature. 2006 May 11;441(7090):179-85. doi: 10.1038/nature04702. Epub 2006 Apr 2.