Jacobsen Ramune, Frederiksen Peder, Heitmann Berit L
J Pediatr Endocrinol Metab. 2016 Apr;29(4):417-24. doi: 10.1515/jpem-2015-0393.
We aimed to assess the association between exposure to sunshine during gestation and the risk of type 1 diabetes (T1D) in Danish children.
The study population included 331,623 individuals born in Denmark from 1983 to 1988; 886 (0.26%) developed T1D by the age of 15 years. The values of sunshine hours were obtained from the Danish Meteorological Institute. Gestational exposure to sunshine was calculated by summing recorded monthly sunshine hours during the full 9 months prior to the month of birth. The linear variable then was split into two categories separated by the median value.
Cox regression models showed that more sunshine during the third gestational trimester was associated with lower hazards (HR) of T1D at age 5-9 years in males: HR (95% CI): 0.60 (0.43-0.84), p=0.003. Our results should be considered in the context of evidence-based recommendations to the public about skin protection from the sun.
我们旨在评估丹麦儿童孕期日照暴露与1型糖尿病（T1D）风险之间的关联。
研究人群包括1983年至1988年在丹麦出生的331,623人；其中886人（0.26%）在15岁前患T1D。日照小时数数据来自丹麦气象研究所。孕期日照暴露通过计算出生月份前完整9个月记录的每月日照小时数总和得出。然后将线性变量按中位数分为两类。
Cox回归模型显示，孕期第三个月日照较多与男性5至9岁时患T1D的较低风险（HR）相关：HR（95%CI）：0.60（0.43 - 0.84），p = 0.003。在向公众提供关于防晒的循证建议时，应考虑我们的研究结果。
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