脂质紊乱是否与人类嗜T淋巴细胞病毒1型感染在女性中占优势有关？
Are lipid disorders involved in the predominance of human T-lymphotropic virus-1 infections in women?
作者信息
Carvalho Luciana Debortoli de, Gadelha Sandra Rocha, Marin Lauro Juliano, Brito-Melo Gustavo Eustaquio Alvim, Martins Camila Pacheco Silveira, Fonseca Flavio Guimarães da, Barbosa-Stancioli Edel Figueiredo
机构信息
Departamento de Ciências Biológicas, Universidade Estadual de Santa Cruz, Ilhéus, Bahia, Brazil.
Departamento de Saúde, Universidade Estadual de Santa Cruz, Ilhéus, Bahia, Brazil.
出版信息
Rev Soc Bras Med Trop. 2015 Nov-Dec;48(6):759-61. doi: 10.1590/0037-8682-0068-2015.
INTRODUCTION
The human T-lymphotropic virus-1 (HTLV-1) is associated with chronic inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a chronic inflammatory disease. Disturbances in lipid metabolism are involved in inflammatory and demyelinating diseases.
METHODS
Plasma levels of triglycerides, total cholesterol, and fractions of HTLV-1-infected individuals of both sexes with different clinical progressions were determined.
RESULTS
Elevated levels of triglyceride and very low-density lipoproteins (VLDL) were exclusively detected in HTLV-1-infected women from asymptomatic and HAM/TSP groups compared with uninfected individuals (p = 0.02).
CONCLUSIONS
Elevated triglyceride and VLDL levels in HTLV-1-infected women may be related to the predominance of HAM/TSP in women.
引言
人类嗜T淋巴细胞病毒1型（HTLV-1）与慢性炎症性疾病有关，如HTLV-1相关脊髓病/热带痉挛性截瘫（HAM/TSP），这是一种慢性炎症性疾病。脂质代谢紊乱与炎症性和脱髓鞘性疾病有关。
方法
测定了不同临床进展的男女HTLV-1感染个体的血浆甘油三酯、总胆固醇水平及组分。
结果
与未感染个体相比，仅在无症状和HAM/TSP组的HTLV-1感染女性中检测到甘油三酯和极低密度脂蛋白（VLDL）水平升高（p = 0.02）。
结论
HTLV-1感染女性中甘油三酯和VLDL水平升高可能与HAM/TSP在女性中的优势有关。
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