Aller-Morán Luis Miguel, Martínez-Lobo Francisco Javier, Rubio Pedro, Carvajal Ana
Infectious Diseases and Epidemiology Unit, Faculty of Veterinary, University of León, 24071 León, Spain.
Infectious Diseases and Epidemiology Unit, Faculty of Veterinary, University of León, 24071 León, Spain.
Res Vet Sci. 2015 Dec;103:51-3. doi: 10.1016/j.rvsc.2015.08.013. Epub 2015 Sep 5.
Flumequine is a quinolone derivative used in veterinary medicine to treat enteric infections, mainly those caused by Gram negative bacteria and also some Gram positive. Some recent reports by field practitioners have suggested that its use in swine dysentery outbreaks can minimize the impact of this disease. This study aims to evaluate the in vitro anti-Brachyspira hyodysenteriae activity of flumequine. Forty eight field isolates of the bacterium were evaluated using a microdilution test. The lack of colon bioavailability studies of flumequine in pigs makes it difficult to establish the true efficacy of this antibiotic for swine dysentery control. Nonetheless, the relatively high values of MIC50 (50 μg/mL) and MBC50 (50 μg/mL) obtained suggest poor activity against B. hyodysenteriae. Flumequine activity in swine dysentery outbreaks could be related to its activity against other bacteria, different from B. hyodysenteriae, engaged in swine dysentery pathogenesis.
氟甲喹是一种喹诺酮衍生物，用于兽医学治疗肠道感染，主要是由革兰氏阴性菌引起的感染，也包括一些革兰氏阳性菌。一些现场从业者最近的报告表明，在猪痢疾疫情中使用它可以将这种疾病的影响降至最低。本研究旨在评估氟甲喹对猪痢疾短螺旋体的体外抗菌活性。使用微量稀释试验对该细菌的48株现场分离株进行了评估。由于缺乏氟甲喹在猪体内结肠生物利用度的研究，难以确定这种抗生素对猪痢疾控制的真正疗效。尽管如此，获得的相对较高的MIC50（50μg/mL）和MBC50（50μg/mL）值表明其对猪痢疾短螺旋体的活性较差。氟甲喹在猪痢疾疫情中的活性可能与其对其他不同于猪痢疾短螺旋体的细菌的活性有关，这些细菌参与猪痢疾的发病机制。
