Madsen C
Institute of Toxicology, National Food Agency, Søborg, Denmark.
Lab Anim. 1989 Jul;23(3):241-7. doi: 10.1258/002367789780810572.
In a carcinogenicity study 443 out of 956 rats had chaff from oat and barley in the mouth between the molars and the gingiva. These foreign bodies caused chronic irritation and inflammation. In 173 animals disruption of tissue caused by the foreign bodies led to pathological communication between the mouth, pharynx and nose. Carcinomas in the oral, pharyngeal or nasal cavity were found in 101 of the 443 animals. Twenty-two animals died and 96 were killed because of intestinal gaseous distension. The intestinal distension was related significantly to the pathological communication between the mouth and pharynx/nose. The study shows that the foreign body-induced chronic irritation and inflammation in the epithelium of the mouth, pharynx and nose can lead to formation of squamous-cell carcinomas. The pathogenesis of the intestinal distension is discussed.
在一项致癌性研究中，956只大鼠中有443只在臼齿和牙龈之间的口腔中有燕麦和大麦的谷壳。这些异物引起了慢性刺激和炎症。在173只动物中，异物导致的组织破坏致使口腔、咽部和鼻腔之间出现病理性连通。在这443只动物中，有101只在口腔、咽部或鼻腔发现了癌。22只动物死亡，96只因肠道胀气而被处死。肠道胀气与口腔和咽部/鼻腔之间的病理性连通显著相关。该研究表明，异物引起的口腔、咽部和鼻腔上皮的慢性刺激和炎症可导致鳞状细胞癌的形成。文中还讨论了肠道胀气的发病机制。
