Charlesworth J A, Pussell B A, Roy L P, Lawrence S, Robertson M R
Aust N Z J Med. 1977 Feb;7(1):23-6. doi: 10.1111/j.1445-5994.1977.tb03351.x.
The complement system was investigated in 34 patients with infectious mononucleosis. Three had specific complications: one haemolytic anaemia, one severe arthralgia/myalgia and one proliferative glomerulonephritis. Complement changes consistent with classical pathway consumption were seen in ten of the uncomplicated group and the patients with haemolytic anaemia and arthralgia/myalgia. The patient with glomerulonephritis showed evidence of alternative pathway utilisation including C3 splitting activity and the deposition of properdin on renal biopsy. The complement findings suggest that circulating immune complexes are common in such patients and are likely to play a role in the pathogenesis of the complications. It is proposed that both complement pathways may be required for the effective clearance of viral material from the circulation.
对34例传染性单核细胞增多症患者的补体系统进行了研究。3例出现特定并发症：1例溶血性贫血、1例严重关节痛/肌痛和1例增殖性肾小球肾炎。在无并发症组以及患有溶血性贫血和关节痛/肌痛的患者中，有10例出现了与经典途径消耗相符的补体变化。患有肾小球肾炎的患者显示出替代途径利用的证据，包括C3裂解活性以及备解素在肾活检中的沉积。补体研究结果表明，循环免疫复合物在这类患者中很常见，并且可能在并发症的发病机制中起作用。有人提出，两条补体途径对于从循环中有效清除病毒物质可能都是必需的。
