Wands J R, Perrotto J L, Isselbacher K J
Am J Med. 1976 Feb;60(2):269-72. doi: 10.1016/0002-9343(76)90436-8.
The role of immune complex formation was investigated in a patient with infectious mononucleosis complicated by an urticarial rash. Circulating cryoprotein immune complexes were identified during the urticarial phase of the illness, and disappeared during recovery. These complexes were composed of immunoglobulins G (IgG), M (IgM) and A (IgA), complement components C3, C4 and C5, Epstein-Barr (EB) virus capsid antibody and particles resembling EB virus. The IgG subtypes identified in the immune complexes were the complement fixing IgG-1, IgG-2 and IgG-3. The C3 activator of the properdin complex was detected in serum obtained during that acute phase but not after recovery. Thus, the transient appearance of circulating complement-fixing immune complexes was associated in this patient with activation of both classic and alternate complement pathways. The findings suggest that these complexes may be involved in the rash associated with infectious mononucleosis.
在一名患有传染性单核细胞增多症并伴有荨麻疹样皮疹的患者中，对免疫复合物形成的作用进行了研究。在疾病的荨麻疹阶段发现了循环冷蛋白免疫复合物，而在康复过程中消失。这些复合物由免疫球蛋白G（IgG）、M（IgM）和A（IgA）、补体成分C3、C4和C5、爱泼斯坦-巴尔（EB）病毒衣壳抗体以及类似EB病毒的颗粒组成。在免疫复合物中鉴定出的IgG亚型是具有补体固定作用的IgG-1、IgG-2和IgG-3。在急性期获得的血清中检测到了备解素复合物中的C3激活剂，但康复后未检测到。因此，在该患者中，循环补体固定免疫复合物的短暂出现与经典和替代补体途径的激活有关。这些发现表明，这些复合物可能与传染性单核细胞增多症相关的皮疹有关。
