Seyfizadeh Narges, Seyfizadeh Nayer, Gharibi Tohid, Babaloo Zohreh
Immunology Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.
Immunology Department, Faculty of Medicine, Tabriz University of Medical Sciences , Tabriz , Iran.
Acta Microbiol Immunol Hung. 2015 Dec;62(4):341-78. doi: 10.1556/030.62.2015.4.2.
Interleukin-13 (IL-13) as a pleiotropic cytokine acts through the IL-13Ra1/IL-4Ra complex to induce activation responses which contribute to the inflammatory diseases. Genetic polymorphisms in IL-13 and its receptor components have been proved to be associated with higher disease prevalence rates. Animal models such as in IL-13 deficient mice and transgenic animals also have been confirmed the critical role of this cytokine in the immune responses, mostly by IL-13 neutralization and IL-13/IL-4 dual neutralization strategies. This review highlights IL-13 structure as well as its pivotal roles in the normal physiologic and pathologic states. It is followed by a section on the recent findings on IL-13 receptors and signalling mechanisms to briefly summarize its functions in the immune systems. IL-13 roles in the human diseases such as asthma, systematic sclerosis, and some inflammatory diseases are described concisely. Finally some of the ongoing therapeutic applications are presented to comprehensively review IL-13 mediator roles.
白细胞介素-13（IL-13）作为一种多效性细胞因子，通过IL-13Ra1/IL-4Ra复合物发挥作用，诱导激活反应，这些反应会导致炎症性疾病。IL-13及其受体成分的基因多态性已被证明与更高的疾病患病率相关。动物模型，如IL-13缺陷小鼠和转基因动物，也证实了这种细胞因子在免疫反应中的关键作用，主要是通过IL-13中和和IL-13/IL-4双重中和策略。本综述重点介绍了IL-13的结构及其在正常生理和病理状态中的关键作用。接下来是关于IL-13受体和信号传导机制的最新研究结果的部分，以简要总结其在免疫系统中的功能。简要描述了IL-13在人类疾病如哮喘、系统性硬化症和一些炎症性疾病中的作用。最后介绍了一些正在进行的治疗应用，以全面综述IL-13的介质作用。
