Laing Stacey, Gracie Kirsten, Faulds Karen
Centre for Molecular Nanometrology, WestCHEM, Pure and Applied Chemistry, University of Strathclyde, Technology and Innovation Centre, 99 George Street, Glasgow, G1 1RD, UK.
Chem Soc Rev. 2016 Apr 7;45(7):1901-1918. doi: 10.1039/c5cs00644a. Epub 2015 Dec 21.
The ability to detect multiple disease-related targets from a single biological sample in a quick and reliable manner is of high importance in diagnosing and monitoring disease. The technique known as surface enhanced Raman scattering (SERS) has been developed for the simultaneous detection of multiple targets present in biological samples. Advances in the SERS method have allowed for the sensitive and specific detection of biologically relevant targets, such as DNA and proteins, which could be useful for the detection and control of disease. This review focuses on the strengths of SERS for the detection of target molecules from complex mixtures and the clinical relevance of recent work combining SERS with multiplexed detection of biological targets.
能够以快速且可靠的方式从单一生物样本中检测多个疾病相关靶点，对于疾病的诊断和监测至关重要。一种名为表面增强拉曼散射（SERS）的技术已被开发用于同时检测生物样本中存在的多个靶点。SERS方法的进展使得能够灵敏且特异检测生物学相关靶点，如DNA和蛋白质，这可能对疾病的检测和控制有用。本综述重点关注SERS从复杂混合物中检测目标分子的优势，以及近期将SERS与生物靶点多重检测相结合的工作的临床相关性。
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