在阿格斯II型视网膜假体患者中使用无动力植入物进行结构和功能磁共振成像采集的可行性：一项病例研究。
Feasibility of Structural and Functional MRI Acquisition with Unpowered Implants in Argus II Retinal Prosthesis Patients: A Case Study.
作者信息
Cunningham Samantha I, Shi Yonggang, Weiland James D, Falabella Paulo, Olmos de Koo Lisa C, Zacks David N, Tjan Bosco S
机构信息
Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
Laboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
出版信息
Transl Vis Sci Technol. 2015 Dec 8;4(6):6. doi: 10.1167/tvst.4.6.6. eCollection 2015 Dec.
PURPOSE
Magnetic resonance imaging (MRI) can measure the effects of vision loss and recovery on brain function and structure. In this case study, we sought to determine the feasibility of acquiring anatomical and functional MRI data in recipients of the Argus II epiretinal prosthesis system.
METHODS
Following successful implantation with the Argus II device, two retinitis pigmentosa (RP) patients completed MRI scans with their implant unpowered to measure primary visual cortex (V1) functional responses to a tactile task, whole-brain morphometry, V1 cortical thickness, and diffusion properties of the optic tract and optic radiation. Measurements in the subjects with the Argus II implant were compared to measurements obtained previously from RP patients and sighted individuals.
RESULTS
The presence of the Argus II implant resulted in artifacts that were localized around the patient's implanted eye and did not extend into cortical regions or white matter tracts associated with the visual system. Structural data on V1 cortical thickness and the retinofugal tract obtained from the two Argus II subjects fell within the ranges of sighted and RP groups. When compared to the RP and sighted subjects, Argus II patients' tactile-evoked cross-modal functional MRI (fMRI) blood oxygen level-dependent (BOLD) responses in V1 also fell within the range of either sighted or RP groups, apparently depending on time since implantation.
CONCLUSIONS
This study demonstrates that successful acquisition and quantification of structural and functional MR images are feasible in the presence of the inactive implant and provides preliminary information on functional changes in the brain that may follow sight restoration treatments.
TRANSITIONAL RELEVANCE
Successful MRI and fMRI acquisition in Argus II recipients demonstrates feasibility of using MRI to study the effect of retinal prosthesis use on brain structure and function.
目的
磁共振成像（MRI）可测量视力丧失及恢复对脑功能和结构的影响。在本病例研究中，我们试图确定在接受阿格斯II型视网膜外植体系统的患者中获取解剖学和功能性MRI数据的可行性。
方法
在成功植入阿格斯II型设备后，两名视网膜色素变性（RP）患者在未开启植入设备的情况下完成了MRI扫描，以测量初级视觉皮层（V1）对触觉任务的功能反应、全脑形态学、V1皮层厚度以及视束和视辐射的扩散特性。将阿格斯II型植入患者的测量结果与先前从RP患者和视力正常个体获得的测量结果进行比较。
结果
阿格斯II型植入物的存在导致伪影，这些伪影局限于患者植入眼周围，未延伸至与视觉系统相关的皮质区域或白质束。从两名阿格斯II型受试者获得的V1皮层厚度和视网膜神经纤维束的结构数据落在视力正常组和RP组的范围内。与RP和视力正常的受试者相比，阿格斯II型患者在V1中由触觉诱发的跨模态功能MRI（fMRI）血氧水平依赖（BOLD）反应也落在视力正常组或RP组的范围内，这显然取决于植入后的时间。
结论
本研究表明，在存在未激活植入物的情况下，成功采集和量化结构和功能MR图像是可行的，并提供了关于视力恢复治疗后大脑功能变化的初步信息。
过渡相关性
在阿格斯II型接受者中成功进行MRI和fMRI采集证明了使用MRI研究视网膜假体对脑结构和功能影响的可行性。
Zotero 插件