夜间腿部痉挛的奎宁治疗安慰剂对照试验。
Placebo-controlled trial of quinine therapy for nocturnal leg cramps.
作者信息
Fung M C, Holbrook J H
出版信息
West J Med. 1989 Jul;151(1):42-4.
A prospective, double-blind, placebo-controlled crossover study of the use of quinine for nocturnal leg cramps was carried out in 8 elderly volunteer patients. The patients were randomly assigned to receive either placebo or 200 mg of quinine sulfate by mouth at bedtime. After 4 weeks of treatment and after a one-week washout period, the group taking quinine switched to placebo and vice versa for another 4 weeks. The differences in the number, duration, and severity of cramps and the side effects were compared. All of the patients had fewer cramps and decreased severity and duration of attacks while receiving quinine. Mild side effects developed in only 2 patients, and these subsided without treatment or discontinuing the medication. We conclude that quinine was effective in relieving nocturnal leg cramps in a selected group of elderly patients.
对8名老年志愿者患者进行了一项前瞻性、双盲、安慰剂对照的交叉研究，以探讨奎宁用于治疗夜间腿部痉挛的效果。患者被随机分配，在睡前口服安慰剂或200毫克硫酸奎宁。经过4周的治疗和1周的洗脱期后，服用奎宁的组改为服用安慰剂，另一组则相反，再进行4周。比较了痉挛的次数、持续时间、严重程度以及副作用的差异。所有患者在服用奎宁期间痉挛次数减少，发作的严重程度和持续时间降低。只有2名患者出现了轻微的副作用，这些副作用在未治疗或未停药的情况下自行消退。我们得出结论，奎宁对特定老年患者群体缓解夜间腿部痉挛有效。
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