Jones K, Castleden C M
Age Ageing. 1983 May;12(2):155-8. doi: 10.1093/ageing/12.2.155.
Muscle cramps are painful and common in elderly patients but have largely escaped medical investigation. Quinine sulphate is usually the sole drug prescribed, even though firm evidence for its efficacy is not available. The results of the present double-blind cross-over study show that quinine was significantly superior to placebo in decreasing the number, severity and duration of nocturnal cramps. Since quinine is not a primary drug in any other condition, further studies of drugs with similar pharmacological actions may thus improve our management of this painful complaint.
肌肉痉挛在老年患者中很常见且令人痛苦，但在很大程度上未受到医学研究的关注。硫酸奎宁通常是唯一开具的药物，尽管其疗效缺乏确凿证据。本双盲交叉研究结果表明，在减少夜间痉挛的次数、严重程度和持续时间方面，奎宁显著优于安慰剂。由于奎宁在其他任何病症中都不是一线药物，因此对具有类似药理作用的药物进行进一步研究可能会改善我们对这种疼痛病症的治疗。
