Kaplan C
Department of Microbiology, University of Reading, England.
Arch Virol. 1989;106(1-2):127-39. doi: 10.1007/BF01311044.
The complications of vaccination against small pox are discussed in relation to the contemplated use as vaccines of recombinant vaccinia viruses carrying the genes for "protective" antigens derived from a range of pathogens. Recombinant vaccines are potentially extremely valuable instruments in the fight against infectious diseases, but caution is needed in their deployment. In addition to the dangers associated with the pathogenicity of various strains of vaccinia virus, there may be problems related to the ecology of the poxviruses--especially orthopoxviruses. Before recombinant vaccinia virus vaccines are widely used, ecological research is urgently needed. It should cover not only the ecology of orthopoxviruses, but also possible interactions between engineered vaccinia viruses released into the environment and wild viruses which may be resident in both target and non-target species in a wide selection of habitats.
本文讨论了天花疫苗接种的并发症，这些并发症与使用携带多种病原体“保护性”抗原基因的重组痘苗病毒作为疫苗的设想用途相关。重组疫苗在对抗传染病方面可能是极具价值的工具，但在其应用中需要谨慎。除了与各种痘苗病毒株致病性相关的危险外，还可能存在与痘病毒生态学相关的问题，尤其是正痘病毒。在重组痘苗病毒疫苗广泛使用之前，迫切需要进行生态学研究。该研究不仅应涵盖正痘病毒的生态学，还应包括释放到环境中的工程痘苗病毒与可能存在于广泛栖息地的目标和非目标物种中的野生病毒之间的可能相互作用。
