Damiani Mario Francesco, Zito Annapaola, Carratù Pierluigi, Falcone Vito Antonio, Bega Elioda, Scicchitano Pietro, Ciccone Marco Matteo, Resta Onofrio
Institute of Respiratory Disease, University of Bari, Bari, Italy.
Section of Cardiovascular Disease, University of Bari, Bari, Italy.
Biochem Res Int. 2015;2015:984193. doi: 10.1155/2015/984193. Epub 2015 Dec 1.
Background and Aims. It is widely accepted that obstructive sleep apnea (OSA) is independently associated with atherosclerosis. Similar to OSA, hypertension (HTN) is a condition associated with atherosclerosis. However, to date, the impact of the simultaneous presence of OSA and HTN on the risk of atherosclerosis has not been extensively studied. The aim of this study was to evaluate the consequences of the coexistence of OSA and HTN on carotid intima-media thickness (IMT) and on inflammatory markers of atherosclerosis (such as interleukin- [IL-] 6 and pentraxin- [PTX-] 3). Methods. The study design allowed us to define 4 groups: (1) controls (n = 30); (2) OSA patients without HTN (n = 30); (3) HTN patients without OSA (n = 30); (4) patients with OSA and HTN (n = 30). In the morning after portable monitoring (between 7 am and 8 am), blood samples were collected, and carotid IMT was measured. Results. Carotid IMT, IL-6, and PTX-3 in OSA normotensive patients and in non-OSA HTN subjects were significantly higher compared to control subjects; in addition, in OSA hypertensive patients they were significantly increased compared to OSA normotensive, non-OSA HTN, or control subjects. Conclusions. OSA and HTN have an additive role in the progression of carotid atherosclerosis and in blood levels of inflammatory markers for atherosclerosis, such as interleukin-6 and pentraxin-3.
背景与目的。阻塞性睡眠呼吸暂停（OSA）与动脉粥样硬化独立相关，这一观点已被广泛接受。与OSA类似，高血压（HTN）也是一种与动脉粥样硬化相关的病症。然而，迄今为止，OSA和HTN同时存在对动脉粥样硬化风险的影响尚未得到广泛研究。本研究的目的是评估OSA和HTN共存对颈动脉内膜中层厚度（IMT）以及动脉粥样硬化炎症标志物（如白细胞介素 - [IL -] 6和五聚素 - [PTX -] 3）的影响。方法。本研究设计将受试者分为4组：（1）对照组（n = 30）；（2）无HTN的OSA患者（n = 30）；（3）无OSA的HTN患者（n = 30）；（4）患有OSA和HTN的患者（n = 30）。在便携式监测后的早晨（上午7点至8点之间）采集血样，并测量颈动脉IMT。结果。与对照组相比，OSA血压正常患者和非OSA的HTN受试者的颈动脉IMT、IL - 6和PTX - 3显著更高；此外，与OSA血压正常、非OSA的HTN或对照组受试者相比，OSA高血压患者的上述指标显著升高。结论。OSA和HTN在颈动脉粥样硬化进展以及动脉粥样硬化炎症标志物（如白细胞介素 - 6和五聚素 - 3）的血液水平方面具有叠加作用。
