Gerdts Volker
Berl Munch Tierarztl Wochenschr. 2015 Nov-Dec;128(11-12):456-63.
Adjuvants are used to improve the immune response to vaccines. Formulation with adjuvants can result in an earlier onset of immunity, an overall stronger immune response, a specific type of immunity, or a longer duration of immunity to the vaccine. Adjuvants were discovered empirically, and for decades, have been used in both humans and animals without understanding the mechanisms of action. With an improved understanding of the immune system, and in particular the interplay between innate and adaptive immunity, we are now getting better insight into the function of adjuvants. As a result, new adjuvants are being developed that are safe and highly effective for common use in humans and animals, as well as for use in high risk populations such as immunocompromised animals, neonates or very old animals. Furthermore, adjuvants can help to reduce the amount of antigen needed in the vaccine, increase the stability of the vaccine and enable alternatiye administration routes such as needle-free delivery of the vaccine. Here, I will provide an over view of the existing adjuvant technologies for veterinary vaccines and provide an outlook into some of the new technologies in preclinical and clinical development.
佐剂用于增强对疫苗的免疫反应。与佐剂一起配制可导致免疫反应更早开始、整体免疫反应更强、产生特定类型的免疫或对疫苗的免疫持续时间更长。佐剂是通过经验发现的,几十年来,一直在人类和动物中使用,却并不了解其作用机制。随着对免疫系统,特别是先天免疫和适应性免疫之间相互作用的进一步了解,我们现在对佐剂的功能有了更深入的认识。因此,正在开发新的佐剂,这些佐剂安全且高效,可普遍用于人类和动物,也可用于免疫功能低下的动物、新生儿或非常年老的动物等高风险群体。此外,佐剂有助于减少疫苗中所需的抗原量,提高疫苗的稳定性,并实现替代给药途径,如无针接种疫苗。在此,我将概述现有的兽用疫苗佐剂技术,并展望一些处于临床前和临床开发阶段的新技术。
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