文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

兽用疫苗佐剂——类型及作用方式

Adjuvants for veterinary vaccines--types and modes of action.

作者信息

Gerdts Volker

出版信息

Berl Munch Tierarztl Wochenschr. 2015 Nov-Dec;128(11-12):456-63.


DOI:
PMID:26697712
Abstract

Adjuvants are used to improve the immune response to vaccines. Formulation with adjuvants can result in an earlier onset of immunity, an overall stronger immune response, a specific type of immunity, or a longer duration of immunity to the vaccine. Adjuvants were discovered empirically, and for decades, have been used in both humans and animals without understanding the mechanisms of action. With an improved understanding of the immune system, and in particular the interplay between innate and adaptive immunity, we are now getting better insight into the function of adjuvants. As a result, new adjuvants are being developed that are safe and highly effective for common use in humans and animals, as well as for use in high risk populations such as immunocompromised animals, neonates or very old animals. Furthermore, adjuvants can help to reduce the amount of antigen needed in the vaccine, increase the stability of the vaccine and enable alternatiye administration routes such as needle-free delivery of the vaccine. Here, I will provide an over view of the existing adjuvant technologies for veterinary vaccines and provide an outlook into some of the new technologies in preclinical and clinical development.

摘要

佐剂用于增强对疫苗的免疫反应。与佐剂一起配制可导致免疫反应更早开始、整体免疫反应更强、产生特定类型的免疫或对疫苗的免疫持续时间更长。佐剂是通过经验发现的,几十年来,一直在人类和动物中使用,却并不了解其作用机制。随着对免疫系统,特别是先天免疫和适应性免疫之间相互作用的进一步了解,我们现在对佐剂的功能有了更深入的认识。因此,正在开发新的佐剂,这些佐剂安全且高效,可普遍用于人类和动物,也可用于免疫功能低下的动物、新生儿或非常年老的动物等高风险群体。此外,佐剂有助于减少疫苗中所需的抗原量,提高疫苗的稳定性,并实现替代给药途径,如无针接种疫苗。在此,我将概述现有的兽用疫苗佐剂技术,并展望一些处于临床前和临床开发阶段的新技术。

相似文献

[1]
Adjuvants for veterinary vaccines--types and modes of action.

Berl Munch Tierarztl Wochenschr. 2015

[2]
Novel Adjuvants and Immunomodulators for Veterinary Vaccines.

Methods Mol Biol. 2016

[3]
[Improvement of veterinary vaccines through the use of new adjuvants].

Tijdschr Diergeneeskd. 1991-5-15

[4]
Unmet needs in modern vaccinology: adjuvants to improve the immune response.

Vaccine. 2010-8-31

[5]
Vaccine adjuvants: role and mechanisms of action in vaccine immunogenicity.

Drug Discov Today. 2003-10-15

[6]
Adjuvants for Animal Vaccines.

Viral Immunol. 2018

[7]
Progress, challenges and opportunities in fish vaccine development.

Fish Shellfish Immunol. 2019-4-27

[8]
Modes of Action for Mucosal Vaccine Adjuvants.

Viral Immunol. 2017

[9]
The science of adjuvants.

Expert Rev Vaccines. 2007-10

[10]
Vaccine adjuvants: smart components to boost the immune system.

Arch Pharm Res. 2017-10-13

引用本文的文献

[1]
One Health adjuvant selection for vaccines against zoonotic infections.

Explor Med. 2025

[2]
Stability of closed and needle-punctured vials of Porvac® subunit vaccine against classical swine fever subjected to thermal stress.

BMC Vet Res. 2024-11-15

[3]
Immunogenicity of a novel inactivated canine adenovirus type 2 variant vaccine for dogs.

Clin Exp Vaccine Res. 2024-7

[4]
Transmission-Blocking Vaccines against Schistosomiasis Japonica.

Int J Mol Sci. 2024-1-30

[5]
Porcine Interleukin-17 and 22 Co-Expressed by Yarrowia lipolytica Enhance Immunity and Increase Protection against Bacterial Challenge in Mice and Piglets.

Biology (Basel). 2022-11-30

[6]
Exosome-Based Vaccines: Pros and Cons in the World of Animal Health.

Viruses. 2021-7-29

[7]
Trials for preparation and evaluation of a combined inactivated reassorted H5N1 and O157 vaccine in poultry.

Vet World. 2021-6

[8]
Effectiveness of Chitosan Nanoparticles in Development of Pentavalent Clostridial Toxoid Vaccine in Terms of Clinical Pathology Elements and Immunological Responses.

Arch Razi Inst. 2020-10

[9]
Enhancement of Immune Response and Anti-Infection of Mice by Porcine Antimicrobial Peptides and Interleukin-4/6 Fusion Gene Encapsulated in Chitosan Nanoparticles.

Vaccines (Basel). 2020-9-21

[10]
Cloning and Expression of the Tibetan Pig Interleukin-23 Gene and Its Promotion of Immunity of Pigs to PCV2 Vaccine.

Vaccines (Basel). 2020-5-26

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索