Burakova Yulia, Madera Rachel, McVey Scott, Schlup John R, Shi Jishu
1 Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University , Manhattan, Kansas.
2 Department of Chemical Engineering, College of Engineering, Kansas State University , Manhattan, Kansas.
Viral Immunol. 2018 Jan/Feb;31(1):11-22. doi: 10.1089/vim.2017.0049. Epub 2017 Jun 15.
Vaccines are essential tools for the prevention and control of infectious diseases in animals. One of the most important steps in vaccine development is the selection of a suitable adjuvant. The focus of this review is the adjuvants used in vaccines for animals. We will discuss current commercial adjuvants and experimental formulations with attention to mineral salts, emulsions, bacterial-derived components, saponins, and several other immunoactive compounds. In addition, we will also examine the mechanisms of action for different adjuvants, examples of adjuvant combinations in one vaccine formulation, and challenges in the research and development of veterinary vaccine adjuvants.
疫苗是预防和控制动物传染病的重要工具。疫苗研发中最重要的步骤之一是选择合适的佐剂。本综述的重点是用于动物疫苗的佐剂。我们将讨论当前的商业佐剂和实验制剂，重点关注矿物盐、乳剂、细菌衍生成分、皂苷和其他几种免疫活性化合物。此外，我们还将研究不同佐剂的作用机制、一种疫苗制剂中佐剂组合的实例，以及兽用疫苗佐剂研发中的挑战。
