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Differentiating virulent 027 and non-027 Clostridium difficile strains by molecular methods.通过分子方法区分毒力强的027型和非027型艰难梭菌菌株。
Expert Rev Mol Diagn. 2015;15(9):1225-9. doi: 10.1586/14737159.2015.1069710. Epub 2015 Aug 4.
2
In the Endemic Setting, Clostridium difficile Ribotype 027 Is Virulent But Not Hypervirulent.在地方病环境中，艰难梭菌核糖体分型027具有致病性，但并非高致病性。
Infect Control Hosp Epidemiol. 2015 Nov;36(11):1318-23. doi: 10.1017/ice.2015.187. Epub 2015 Aug 20.
3
Burden of Clostridium difficile infection in the United States.美国艰难梭菌感染的负担
N Engl J Med. 2015 Jun 11;372(24):2369-70. doi: 10.1056/NEJMc1505190.
4
C. difficile ribotype 027 or 176?艰难梭菌核糖体分型027还是176？
Folia Microbiol (Praha). 2014 Nov;59(6):523-6. doi: 10.1007/s12223-014-0323-5. Epub 2014 Jun 27.
5
Rapid whole-genome sequencing for detection and characterization of microorganisms directly from clinical samples.直接从临床样本中检测和鉴定微生物的快速全基因组测序。
J Clin Microbiol. 2014 Jan;52(1):139-46. doi: 10.1128/JCM.02452-13. Epub 2013 Oct 30.
6
Challenges for standardization of Clostridium difficile typing methods.艰难梭菌分型方法标准化面临的挑战。
J Clin Microbiol. 2013 Sep;51(9):2810-4. doi: 10.1128/JCM.00143-13. Epub 2013 Jun 19.
7
Current application and future perspectives of molecular typing methods to study Clostridium difficile infections.目前分子分型方法在研究艰难梭菌感染中的应用及未来展望。
Euro Surveill. 2013 Jan 24;18(4):20381. doi: 10.2807/ese.18.04.20381-en.
8
Evaluation of Clostridium difficile fecal load and limit of detection during a prospective comparison of two molecular tests, the illumigene C. difficile and Xpert C. difficile/Epi tests.在一项比较两种分子检测方法（illumigene C. difficile 和 Xpert C. difficile/Epi 检测）的前瞻性研究中，评估艰难梭菌粪便负荷和检测限。
J Clin Microbiol. 2013 Jan;51(1):278-80. doi: 10.1128/JCM.02120-12. Epub 2012 Oct 10.
9
Detection of toxigenic Clostridium difficile: comparison of the cell culture neutralization, Xpert C. difficile, Xpert C. difficile/Epi, and Illumigene C. difficile assays.艰难梭菌毒素检测：细胞培养中和试验、Xpert C. difficile 检测、Xpert C. difficile/Epi 检测和 Illumigene C. difficile 检测的比较。
J Clin Microbiol. 2012 Apr;50(4):1331-5. doi: 10.1128/JCM.06597-11. Epub 2012 Jan 25.
10
Presumptive identification of Clostridium difficile strain 027/NAP1/BI on Cepheid Xpert: interpret with caution.在赛沛Xpert系统上对艰难梭菌027/NAP1/BI菌株进行推测性鉴定：谨慎解读。
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多位点序列分型与Xpert艰难梭菌/疫情检测法用于鉴定艰难梭菌027/NAP1/BI的比较

Comparison of Multilocus Sequence Typing and the Xpert C. difficile/Epi Assay for Identification of Clostridium difficile 027/NAP1/BI.

作者信息

McMillen Tracy, Kamboj Mini, Babady N Esther

机构信息

Clinical Microbiology Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA.

Infection Control Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA Department of Medicine, Weill Cornell Medical College, New York, New York, USA.

出版信息

J Clin Microbiol. 2016 Mar;54(3):775-8. doi: 10.1128/JCM.03075-15. Epub 2015 Dec 23.

DOI:10.1128/JCM.03075-15
PMID:26699700
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4767941/
Abstract

Clostridium difficile 027/NAP1/BI is the most common C. difficile strain in the United States. The Xpert C. difficile/Epi assay allows rapid, presumptive identification of C. difficile NAP1. We compared Xpert C. difficile/Epi to multilocus sequence typing for identification of C. difficile NAP1 and found "very good" agreement at 97.9% (κ = 0.86; 95% confidence interval, 0.80 to 0.91).

摘要

艰难梭菌027/NAP1/BI是美国最常见的艰难梭菌菌株。Xpert艰难梭菌/流行率检测可快速、初步鉴定艰难梭菌NAP1。我们将Xpert艰难梭菌/流行率检测与多位点序列分型用于鉴定艰难梭菌NAP1进行了比较，发现一致性“非常好”，为97.9%（κ = 0.86；95%置信区间，0.80至0.91）。