Feinstein Aaron J, Peng Kevin A, Bhuta Sunita M, Abemayor Elliot, Mendelsohn Abie H
Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Department of Pathology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Am J Otolaryngol. 2016 Jan-Feb;37(1):17-21. doi: 10.1016/j.amjoto.2015.09.010. Epub 2015 Sep 10.
To describe an experience with laryngeal oncocytic cystadenomas and review the published literature regarding this uncommon diagnosis.
A clinical review of patients presenting with cystic laryngeal masses in an urban academic medical center between January and December 2013 was performed. Three patients, two female and one male, with a mean age of 68 years, were diagnosed with oncocytic cystadenomata of the larynx. Major presenting symptoms included dysphonia, globus, and ipsilateral otalgia. Endoscopic examinations revealed a cystic structure arising from varied subsites of the larynx: laryngeal ventricle, aryepiglottic fold, and pre-epiglottic space. Cross-sectional radiographic imaging was obtained in each case. The patients were treated with transoral (CO2) laser microsurgery (TLM). In all three cases, pathological analysis revealed oncocytic cystadenoma with clear margins.
Oncocytic cystadenoma is a rare entity of the larynx predominantly affecting elderly patients. Clinical presentation and imaging may suggest the diagnosis of an internal laryngocele. Complete excision is both diagnostic and therapeutic, and typically can be achieved using TLM. When clear margins are obtained, no adjuvant therapy is indicated. Although laryngoceles and malignancies are more commonly encountered, oncocytic cystadenomas should remain in the differential of cystic laryngeal masses.
描述喉嗜酸细胞性囊腺瘤的诊治经验，并回顾已发表的关于这一罕见诊断的文献。
对2013年1月至12月间在一家城市学术医疗中心出现喉部囊性肿物的患者进行临床回顾。3例患者，2例女性，1例男性，平均年龄68岁，被诊断为喉嗜酸细胞性囊腺瘤。主要症状包括声音嘶哑、咽部异物感和同侧耳痛。内镜检查显示囊肿结构起源于喉部不同部位：喉室、杓会厌襞和会厌前间隙。每例均进行了横断面影像学检查。患者接受了经口（二氧化碳）激光显微手术（TLM）治疗。所有3例病例的病理分析均显示嗜酸细胞性囊腺瘤，切缘清晰。
嗜酸细胞性囊腺瘤是一种罕见的喉部疾病，主要影响老年患者。临床表现和影像学检查可能提示喉内囊肿的诊断。完整切除既是诊断性的也是治疗性的，通常可通过TLM实现。当切缘清晰时，无需辅助治疗。虽然喉囊肿和恶性肿瘤更为常见，但嗜酸细胞性囊腺瘤仍应列入喉部囊性肿物的鉴别诊断。
