Brandwein M, Huvos A
Department of Pathology, Mount Sinai School of Medicine, New York, NY, USA.
Arch Otolaryngol Head Neck Surg. 1995 Nov;121(11):1302-5. doi: 10.1001/archotol.1995.01890110076014.
To describe an uncommon clinical entity, laryngeal oncocytic salivary adenomas.
While the nomenclature of these lesions may differ depending on their histologic appearance, these tumors are all generally part of a spectrum of clinically benign cystic and papillary lesions derived from oncocytic metaplasia and hyperplasia of minor salivary ducts.
Eight cases of laryngeal oncocytic lesions collected from two institutions. Further clinical background and follow-up data were obtained on five of eight patients.
Patients were mostly in their seventh and eighth decades of life, and all who were questioned had smoking histories. Hoarseness was a common presenting complaint, and all patients had polypoid laryngeal masses. One patient presented with progressive upper airway obstruction, which was ultimately fatal; the laryngeal oncocytic cystadenoma was diagnosed in this case during postmortem examination. The laryngeal lesions were predominantly supraglottic. Histologically, they consisted of oncocytic metaplasia of the minor salivary ducts, cystic dilation, and papillary and microcystic hyperplasia. No recurrences were seen in those patients with follow-up (four of eight).
Laryngeal oncocytic lesions usually present as supraglottic masses in older patients. While they are oncologically benign and nonrecurring after endoscopic removal, they may occasionally be the cause of significant upper airway obstruction.
描述一种罕见的临床实体——喉嗜酸细胞性涎腺腺瘤。
虽然这些病变的命名可能因其组织学表现而异，但这些肿瘤通常都属于一系列临床上良性的囊性和乳头状病变，源自小涎腺导管的嗜酸细胞化生和增生。
从两个机构收集了8例喉部嗜酸细胞性病变病例。对8例患者中的5例进一步获取了临床背景和随访数据。
患者大多处于七、八十岁，所有接受询问的患者都有吸烟史。声音嘶哑是常见的主诉，所有患者均有喉部息肉样肿物。1例患者出现进行性上呼吸道梗阻，最终死亡；该病例在尸检时诊断为喉嗜酸细胞性囊腺瘤。喉部病变主要位于声门上区。组织学上，它们由小涎腺导管的嗜酸细胞化生、囊性扩张以及乳头状和微囊性增生组成。随访患者（8例中的4例）未见复发。
喉部嗜酸细胞性病变通常表现为老年患者的声门上肿物。虽然它们在肿瘤学上是良性且在内镜切除后不会复发，但它们偶尔可能是严重上呼吸道梗阻的原因。
