Fine S, Jewesson B
Department of Psychiatry, University of British Columbia, Vancouver.
Can J Psychiatry. 1989 Jun;34(5):447-9. doi: 10.1177/070674378903400516.
A clinical trial of methylphenidate/placebo on 39 patients is described. Fifteen of 20 parents not keen to give their child methylphenidate did give it, after the trial had shown it was effective. Five out of 19 parents keen to give their child methylphenidate were persuaded not to after it was shown that it was ineffective. Some of the difficulties with the trial are described for example, parents confusing the days the drug is to be given, parents and teachers not filling in the questionnaires and the resistance of certain professionals to giving medication. Patients seem to be more accepting of recommendations to give medication or not, after a medication/placebo trial demonstrated efficacy or lack of efficacy.
描述了一项针对39名患者的哌甲酯/安慰剂临床试验。在试验表明哌甲酯有效后，20名原本不愿给孩子使用哌甲酯的家长中有15名确实给孩子用了药。在表明哌甲酯无效后，19名原本急于给孩子使用哌甲酯的家长中有5名被说服不再用药。文中描述了该试验遇到的一些困难，例如家长混淆给药日期、家长和教师未填写问卷以及某些专业人员对给药的抵触情绪。在药物/安慰剂试验证明有效或无效后，患者似乎更能接受用药或不用药的建议。
