Mukherjee Manjira, Sen Buddhadeb, Pal Siddhartha, Maji Abhishek, Budhadev Darshita, Chattopadhyay Pabitra
Department of Chemistry, Burdwan University, Golapbag, Burdwan 713104, West Bengal, India.
Department of Chemical Sciences, Indian Institute of Science Education and Research, Kolkata, West Bengal 741252, India.
Spectrochim Acta A Mol Biomol Spectrosc. 2016 Mar 15;157:11-16. doi: 10.1016/j.saa.2015.11.032. Epub 2015 Dec 2.
A structurally modified quinazoline derivative (L) acts as highly selective chemosensor for Al(3+) ions in DMSO-H2O (1:9, v/v) over the other competitive metal ions. L shows a red shifted fluorescence after the addition of Al(3+) ions and later the further fluorescence enhancement is due to chelation enhanced fluorescence (CHEF) through inhibition of photoinduced electron transfer (PET). This probe (L) detects Al(3+) ions as low as 9nM in DMSO-H2O (1:9, v/v) at biological pH. The non-cytotoxic probe (L) can efficiently detect the intercellular distribution of Al(3+) ions in living cells under a fluorescence microscope to exhibit its sensible applications in the biological systems.
一种结构修饰的喹唑啉衍生物（L）在二甲基亚砜-水（1:9，v/v）体系中，相对于其他竞争性金属离子，对铝离子（Al(3+)）表现出高度选择性的化学传感作用。加入Al(3+)离子后，L的荧光发生红移，随后进一步的荧光增强是由于通过抑制光诱导电子转移（PET）实现的螯合增强荧光（CHEF）。该探针（L）在生物pH值下的二甲基亚砜-水（1:9，v/v）体系中能检测低至9 nM的Al(3+)离子。这种无细胞毒性的探针（L）能够在荧光显微镜下有效检测活细胞中Al(3+)离子的细胞内分布，从而展示出其在生物系统中的实际应用价值。
