毛花柱仙人球（Pilosocereus gounellei A. Weber ex K. Schum. Bly. ex Rowl.）（仙人掌科）的新型酰胺类化合物及其抗氧化活性
New Alcamide and Anti-oxidant Activity of Pilosocereus gounellei A. Weber ex K. Schum. Bly. ex Rowl. (Cactaceae).
作者信息
Maciel Jéssica K S, Chaves Otemberg S, Brito Filho Severino G, Teles Yanna C F, Fernandes Marianne G, Assis Temilce S, Fernandes Pedro Dantas, de Andrade Alberício Pereira, Felix Leonardo P, Silva Tania M S, Ramos Nathalia S M, Silva Girliane R, de Souza Maria de Fátima Vanderlei
机构信息
Post-Graduation Program in Development and Technological Innovation in Medicines, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900, Brazil.
Post-Graduation Program in Bioactive Natural and Synthetic Products, Health Science Center, Federal University of Paraiba, Campus I, João Pessoa, PB, 58051-900 Brazil.
出版信息
Molecules. 2015 Dec 22;21(1):E11. doi: 10.3390/molecules21010011.
The Cactaceae family is composed by 124 genera and about 1438 species. Pilosocereus gounellei, popularly known in Brazil as xique-xique, is used in folk medicine to treat prostate inflammation, gastrointestinal and urinary diseases. The pioneering phytochemical study of P. gounellei was performed using column chromatography and HPLC, resulting in the isolation of 10 substances: pinostrobin (1), β-sitosterol (2), a mixture of sitosterol 3-O-β-d-glucopyranoside/stigmasterol 3-O-β-d-glucopyranoside (3a/3b), 13²-hydroxyphaeophytin a (4), phaeophytin a (5), a mixture of β-sitosterol and stigmasterol (6a/6b), kaempferol (7), quercetin (8), 7'-ethoxy-trans-feruloyltyramine (mariannein, 9) and trans-feruloyl tyramine (10). Compound 9 is reported for the first time in the literature. The structural characterization of the compounds was performed by analyses of 1-D and 2-D NMR data. In addition, a phenolic and flavonol total content assay was carried out, and the anti-oxidant potential of P. gounellei was demonstrated.
仙人掌科由124个属和约1438个物种组成。皮洛索仙人掌（Pilosocereus gounellei）在巴西俗称西克西克（xique-xique），在民间医学中用于治疗前列腺炎症、胃肠道和泌尿系统疾病。对皮洛索仙人掌进行的开创性植物化学研究采用柱色谱法和高效液相色谱法，分离出10种物质：松属素（1）、β-谷甾醇（2）、谷甾醇3-O-β-D-吡喃葡萄糖苷/豆甾醇3-O-β-D-吡喃葡萄糖苷混合物（3a/3b）、13²-羟基脱镁叶绿素a（4）、脱镁叶绿素a（5）、β-谷甾醇和豆甾醇混合物（6a/6b）山奈酚（7）、槲皮素（8）、7'-乙氧基反式阿魏酰酪胺（玛丽安因，9）和反式阿魏酰酪胺（10）。化合物9是文献中首次报道的。通过一维和二维核磁共振数据分析对化合物进行了结构表征。此外，还进行了酚类和黄酮醇总含量测定，并证明了皮洛索仙人掌的抗氧化潜力。
Zotero 插件