用于多孔生物材料的创新高压制造工艺——综述

Innovative High-Pressure Fabrication Processes for Porous Biomaterials-A Review.

作者信息

Prakasam Mythili, Silvain Jean-François, Largeteau Alain

机构信息

CNRS, Univ. Bordeaux, Bordeaux INP, ICMCB, UMR 5026, F-33600 Pessac, France.

出版信息

Bioengineering (Basel). 2021 Nov 1;8(11):170. doi: 10.3390/bioengineering8110170.

Abstract

Biomaterials and their clinical application have become well known in recent years and progress in their manufacturing processes are essential steps in their technological advancement. Great advances have been made in the field of biomaterials, including ceramics, glasses, polymers, composites, glass-ceramics and metal alloys. Dense and porous ceramics have been widely used for various biomedical applications. Current applications of bioceramics include bone grafts, spinal fusion, bone repairs, bone fillers, maxillofacial reconstruction, etc. One of the common impediments in the bioceramics and metallic porous implants for biomedical applications are their lack of mechanical strength. High-pressure processing can be a viable solution in obtaining porous biomaterials. Many properties such as mechanical properties, non-toxicity, surface modification, degradation rate, biocompatibility, corrosion rate and scaffold design are taken into consideration. The current review focuses on different manufacturing processes used for bioceramics, polymers and metals and their alloys in porous forms. Recent advances in the manufacturing technologies of porous ceramics by freeze isostatic pressure and hydrothermal processing are discussed in detail. Pressure as a parameter can be helpful in obtaining porous forms for biomaterials with increased mechanical strength.

摘要

近年来,生物材料及其临床应用已广为人知,其制造工艺的进步是技术进步的关键步骤。生物材料领域已取得了巨大进展,包括陶瓷、玻璃、聚合物、复合材料、微晶玻璃和金属合金。致密和多孔陶瓷已广泛应用于各种生物医学领域。生物陶瓷目前的应用包括骨移植、脊柱融合、骨修复、骨填充、颌面重建等。生物陶瓷和金属多孔植入物在生物医学应用中的一个常见障碍是它们缺乏机械强度。高压处理可能是获得多孔生物材料的可行解决方案。许多特性,如机械性能、无毒性、表面改性、降解率、生物相容性、腐蚀速率和支架设计等都需要考虑。本综述重点关注用于制造多孔形式的生物陶瓷、聚合物和金属及其合金的不同制造工艺。详细讨论了通过冷冻等静压和水热工艺制造多孔陶瓷的技术最新进展。压力作为一个参数,有助于获得具有更高机械强度的多孔生物材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a467/8614988/07a42554aa41/bioengineering-08-00170-g001.jpg

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