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基于羟基磷灰石的涂层技术综述:生物相容性金属上的溶胶-凝胶和电化学沉积法

A review of hydroxyapatite-based coating techniques: Sol-gel and electrochemical depositions on biocompatible metals.

作者信息

Asri R I M, Harun W S W, Hassan M A, Ghani S A C, Buyong Z

机构信息

Institute of Postgraduate Studies, Universiti Malaysia Pahang, Lebuhraya Tun Razak, 26300 Gambang, Kuantan, Pahang, Malaysia.

Human Engineering Group, Faculty of Mechanical Engineering, Universiti Malaysia Pahang, 26600 Pekan, Pahang, Malaysia.

出版信息

J Mech Behav Biomed Mater. 2016 Apr;57:95-108. doi: 10.1016/j.jmbbm.2015.11.031. Epub 2015 Dec 6.

Abstract

New promising techniques for depositing biocompatible hydroxyapatite-based coatings on biocompatible metal substrates for biomedical applications have continuously been exploited for more than two decades. Currently, various experimental deposition processes have been employed. In this review, the two most frequently used deposition processes will be discussed: a sol-gel dip coating and an electrochemical deposition. This study deliberates the surface morphologies and chemical composition, mechanical performance and biological responses of sol-gel dip coating as well as the electrochemical deposition for two different sample conditions, with and without coating. The review shows that sol-gel dip coatings and electrochemical deposition were able to obtain the uniform and homogeneous coating thickness and high adherent biocompatible coatings even in complex shapes. It has been accepted that both coating techniques improve bone strength and initial osseointegration rate. The main advantages and limitations of those techniques of hydroxyapatite-based coatings are presented. Furthermore, the most significant challenges and critical issues are also highlighted.

摘要

二十多年来,人们一直在不断探索用于在生物相容性金属基底上沉积生物相容性羟基磷灰石基涂层以用于生物医学应用的新的有前景的技术。目前,已经采用了各种实验性沉积工艺。在本综述中,将讨论两种最常用的沉积工艺:溶胶 - 凝胶浸涂法和电化学沉积法。本研究探讨了溶胶 - 凝胶浸涂法以及电化学沉积法在两种不同样品条件下(有涂层和无涂层)的表面形态和化学成分、机械性能以及生物学反应。该综述表明,溶胶 - 凝胶浸涂法和电化学沉积法即使在复杂形状下也能够获得均匀且一致的涂层厚度以及高附着力的生物相容性涂层。人们已经认识到这两种涂层技术都能提高骨强度和初始骨整合率。文中介绍了这些羟基磷灰石基涂层技术的主要优点和局限性。此外,还突出了最重大的挑战和关键问题。

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