Priyadarshini B, Stango Arul Xavier, Balasubramanian M, Vijayalakshmi U
Department of Chemistry, School of Advanced Sciences, VIT Vellore 632 014 Tamil Nadu India
Dept of Metallurgical and Materials Engineering Indian Institute of Technology-Madras (IIT Madras) Chennai 600 036 India.
Nanoscale Adv. 2023 Aug 10;5(18):5054-5076. doi: 10.1039/d3na00235g. eCollection 2023 Sep 12.
With the ultimate goal of providing a novel platform able to inhibit bacterial adhesion, biofilm formation, and anticancer properties, cerium-doped hydroxyapatite films enhanced with magnetite were developed spin-coating. The unique aspect of the current study is the potential for creating cerium-doped hydroxyapatite/FeO coatings on a titanium support to enhance the functionality of bone implants. To assure an increase in the bioactivity of the titanium surface, alkali pretreatment was done before deposition of the apatite layer. Scanning electron microscopy (SEM) in conjunction with energy-dispersive X-ray (EDX) spectroscopy, X-ray diffraction (XRD) analysis, and Fourier transform-infrared (FTIR) spectroscopy were used to evaluate coatings. Coatings demonstrated good efficacy against s and , with the latter showing the highest efficacy. bioactivity in simulated body fluid solution showed this material to be proficient for bone-like apatite formation on the implant surface. Electrochemical impedance spectroscopy was undertaken on intact coatings to examine the barrier properties of composites. We found that spin-coating at 4000 rpm could greatly increase the total resistance. After seeding with osteoblastic populations, Ce-HAP/FeO materials the adhesion and proliferation of cells. The heating capacity of the Ce-HAP/FeO film was optimal at 45 °C at 15 s at a frequency of 318 kHz. Osseointegration depends on many more parameters than hydroxyapatite production, so these coatings have significant potential for use in bone healing and bone-cancer therapy.
为了提供一个能够抑制细菌粘附、生物膜形成并具有抗癌特性的新型平台，通过旋涂法制备了用磁铁矿增强的铈掺杂羟基磷灰石薄膜。本研究的独特之处在于有潜力在钛载体上制备铈掺杂羟基磷灰石/FeO涂层，以增强骨植入物的功能。为确保钛表面生物活性增加，在磷灰石层沉积之前进行了碱预处理。使用扫描电子显微镜（SEM）结合能量色散X射线（EDX）光谱、X射线衍射（XRD）分析和傅里叶变换红外（FTIR）光谱来评估涂层。涂层对s和显示出良好的效果，后者显示出最高的效果。在模拟体液溶液中的生物活性表明这种材料能够在植入物表面形成类骨磷灰石。对完整涂层进行电化学阻抗谱以检查复合材料的阻隔性能。我们发现以4000转/分钟的速度旋涂可以大大增加总电阻。在用成骨细胞接种后，Ce-HAP/FeO材料促进了细胞的粘附和增殖。Ce-HAP/FeO薄膜在318kHz频率下，45℃持续15秒时的热容量最佳。骨整合取决于比羟基磷灰石生成更多的参数，因此这些涂层在骨愈合和骨癌治疗中具有巨大的应用潜力。
