先天性巨细胞病毒感染的预防与治疗进展
Advances in the prevention and treatment of congenital cytomegalovirus infection.
作者信息
James Scott H, Kimberlin David W
机构信息
University of Alabama at Birmingham, Birmingham, Alabama, USA.
出版信息
Curr Opin Pediatr. 2016 Feb;28(1):81-5. doi: 10.1097/MOP.0000000000000305.
Abstract
PURPOSE OF REVIEW
Cytomegalovirus (CMV) is the most common cause of congenital infection in the world. Symptomatic infants are at increased risk of developing permanent sequelae, including sensorineural hearing loss and neurodevelopmental delay. Advances in the treatment and prevention of congenital CMV infection are a high priority nationally and globally.
RECENT FINDINGS
In symptomatic infants, antiviral therapy with 6 months of oral valganciclovir improves hearing and neurodevelopmental outcomes. Strategies to prevent congenital or maternal CMV infections, including the use of CMV hyperimmune globulin and development of a maternal vaccine, have yet to yield positive results.
SUMMARY
The clinical significance of congenital CMV infection, developments in antiviral therapy, and efforts to prevent congenital disease are herein reviewed.
摘要
综述目的
巨细胞病毒（CMV）是全球先天性感染最常见的病因。有症状的婴儿发生永久性后遗症的风险增加，包括感音神经性听力损失和神经发育迟缓。先天性CMV感染的治疗和预防进展在国内和全球都是高度优先事项。
最新发现
对于有症状的婴儿，口服缬更昔洛韦进行6个月的抗病毒治疗可改善听力和神经发育结局。预防先天性或母体CMV感染的策略，包括使用CMV高效价免疫球蛋白和研发母体疫苗，尚未产生阳性结果。
总结
本文综述了先天性CMV感染的临床意义、抗病毒治疗的进展以及预防先天性疾病的努力。
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