Jones C L, Hosking C S, Kincaid-Smith P, Powell H R, Richardson S C, Sennhauser F H, Roberton D M
Department of Immunology, Royal Children's Hospital, Melbourne, Australia.
J Clin Immunol. 1989 Jul;9(4):306-12. doi: 10.1007/BF00918662.
The concentrations of serum IgG and IgM antibodies to polyclonal IgA (IgAp), IgA1, and IgA2 were determined by enzyme immunoassay in 31 patients with IgA nephropathy and 30 healthy controls. Patients with IgA nephropathy had significantly raised concentrations of serum IgA compared to controls (Mann-Whitney U test, P = 0.001) and increased concentrations of conglutinin-binding IgA immune complexes (P = 0.024). No differences in the median concentrations of IgG and IgM anti-IgA antibodies were found between the patients and the controls. In serum samples from healthy controls there was a significant positive correlation between IgM anti-IgAp and IgA immune complex concentrations (P = 0.05), which contrasted with the finding of an inverse correlation between IgM anti-IgAp and IgA immune complex concentrations in patients with IgA nephropathy (P less than 0.05). In addition, the concentrations of conglutinin binding IgM immune complexes in serum were found to correlate with the concentration of IgM anti-IgAp (0.010 less than P less than 0.025), IgM anti-IgA1, and IgM anti-IgA2 (P much less than 0.005 for both) in patients with IgA nephropathy but not in controls. IgM anti-IgA antibodies may be important in augmenting the clearance of IgA immune complexes from the serum of patients with IgA nephropathy.
采用酶免疫分析法测定了31例IgA肾病患者和30名健康对照者血清中针对多克隆IgA（IgAp）、IgA1和IgA2的IgG和IgM抗体浓度。与对照组相比，IgA肾病患者的血清IgA浓度显著升高（曼-惠特尼U检验，P = 0.001），胶固素结合IgA免疫复合物浓度增加（P = 0.024）。患者与对照组之间IgG和IgM抗IgA抗体的中位数浓度无差异。在健康对照者的血清样本中，IgM抗IgAp与IgA免疫复合物浓度之间存在显著正相关（P = 0.05），这与IgA肾病患者中IgM抗IgAp与IgA免疫复合物浓度呈负相关的结果形成对比（P < 0.05）。此外，在IgA肾病患者而非对照组中，发现血清中胶固素结合IgM免疫复合物的浓度与IgM抗IgAp（0.010 < P < 0.025）、IgM抗IgA1和IgM抗IgA2（两者P均远小于0.005）的浓度相关。IgM抗IgA抗体可能在增强IgA免疫复合物从IgA肾病患者血清中的清除方面起重要作用。
