Fan Zhiying, Li Dongdong, Yu Xue, Zhang Yuping, Cai Yong, Jin Jingji, Yu Jihong
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, 130012, P.R. China.
Department of Materials Science, Jilin University, 2699 Qianjin Street, Changchun, 130012, P.R. China.
Chemistry. 2016 Mar 7;22(11):3681-5. doi: 10.1002/chem.201504377. Epub 2016 Jan 25.
Hollow mesoporous silica nanospheres functionalized with aggregation-induced emission (AIE) luminogen tetraphenylethene were prepared by postgrafting method. The as-prepared inorganic-organic hybrid nanospheres show bright blue emission and good biocompatibility as shown by MTT assays. The large cavities of the materials enable high loading of the anticancer drug doxorubicin hydrochloride (DOX), and the mesoporous silica shells allow pH-dependent drug release. The materials can be effectively taken up by cells and function as luminescent bioprobes, demonstrating their potential application in imaging-guided therapy.
通过后接枝法制备了用聚集诱导发光（AIE）发光剂四苯乙烯功能化的中空介孔二氧化硅纳米球。如MTT分析所示，所制备的无机-有机杂化纳米球呈现明亮的蓝色发射和良好的生物相容性。材料的大空腔能够高负载抗癌药物盐酸多柔比星（DOX），介孔二氧化硅壳层允许pH依赖的药物释放。这些材料能够被细胞有效摄取并用作发光生物探针，证明了它们在成像引导治疗中的潜在应用。
