MacIntyre C Raina, Chughtai Abrar Ahmad
School of Public Health and Community Medicine, Samuels Building, Room 325, Faculty of Medicine, University of New South Wales, Sydney, 2052, NSW, Australia.
School of Public Health and Community Medicine, Samuels Building, Room 325, Faculty of Medicine, University of New South Wales, Sydney, 2052, NSW, Australia.
Int J Infect Dis. 2016 Feb;43:58-61. doi: 10.1016/j.ijid.2015.12.011. Epub 2015 Dec 19.
Ebola virus disease (EVD) is an understudied infection and many aspects of viral transmission and clinical course remain unclear. With over 17000 EVD survivors in West Africa, the World Health Organization has focused its strategy on managing survivors and the risk of re-emergence of outbreaks posed by persistence of the virus during convalescence. Sexual transmission from survivors has also been documented following the 2014 epidemic and there are documented cases of survivors readmitted to hospital with 'recurrence' of EVD symptoms. In addition to persistence of virus in survivors, there is also some evidence for 'reinfection' with Ebola virus. In this paper, the evidence for recurrence and reinfection of EVD and implications for epidemic control are reviewed.
埃博拉病毒病（EVD）是一种研究不足的感染性疾病，病毒传播和临床病程的许多方面仍不清楚。西非有超过17000名埃博拉病毒病幸存者，世界卫生组织已将其战略重点放在管理幸存者以及恢复期病毒持续存在引发疫情再次暴发的风险上。2014年疫情之后，也有关于幸存者性传播的记录，并且有记录显示幸存者因埃博拉病毒病症状“复发”再次入院。除了病毒在幸存者体内持续存在外，还有一些证据表明存在埃博拉病毒“再次感染”的情况。本文对埃博拉病毒病复发和再次感染的证据及其对疫情控制的影响进行了综述。
