• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

帕金森病。揭开帕金森病非运动症状的神秘面纱。

Parkinson disease. Unravelling the nonmotor mysteries of Parkinson disease.

机构信息

Maurice Wohl Clinical Neuroscience Institute, King's College London, 5 Cutcombe Road, London SE5 9RT, UK.

出版信息

Nat Rev Neurol. 2016 Jan;12(1):10-1. doi: 10.1038/nrneurol.2015.236.

DOI:10.1038/nrneurol.2015.236
PMID:26714657
Abstract

Parkinson disease (PD) is now regarded as a mixed motor, nonmotor and multiorgan disorder rather than a pure movement disorder. Nonmotor symptoms (NMS) have underpinned this conceptual change, and new criteria for clinical and prodromal diagnosis of PD, incorporating a range of NMS, have recently been published.

摘要

帕金森病(PD)现在被认为是一种混合运动、非运动和多器官障碍,而不仅仅是一种纯粹的运动障碍。非运动症状(NMS)支持了这一概念的转变,最近已经发布了新的临床和前驱期 PD 诊断标准,纳入了一系列 NMS。

相似文献

1
Parkinson disease. Unravelling the nonmotor mysteries of Parkinson disease.帕金森病。揭开帕金森病非运动症状的神秘面纱。
Nat Rev Neurol. 2016 Jan;12(1):10-1. doi: 10.1038/nrneurol.2015.236.
2
Biomarkers of Nonmotor Symptoms in Parkinson's Disease.帕金森病非运动症状的生物标志物
Int Rev Neurobiol. 2017;133:259-289. doi: 10.1016/bs.irn.2017.05.020. Epub 2017 Jun 27.
3
The Nonmotor Features of Parkinson's Disease.帕金森病的非运动症状
Int Rev Neurobiol. 2017;132:33-54. doi: 10.1016/bs.irn.2017.02.016. Epub 2017 Apr 4.
4
Nonmotor fluctuations in Parkinson disease: severity and correlation with motor complications.帕金森病的非运动波动:严重程度与运动并发症的相关性。
Neurology. 2013 Feb 26;80(9):800-9. doi: 10.1212/WNL.0b013e318285c0ed. Epub 2013 Jan 30.
5
MDS research criteria for prodromal Parkinson's disease.前驱期帕金森病的MDS研究标准。
Mov Disord. 2015 Oct;30(12):1600-11. doi: 10.1002/mds.26431.
6
Nonmotor symptoms in nursing home residents with Parkinson's disease: prevalence and effect on quality of life.养老院帕金森病患者的非运动症状:患病率及其对生活质量的影响。
J Am Geriatr Soc. 2013 Oct;61(10):1714-21. doi: 10.1111/jgs.12458. Epub 2013 Oct 1.
7
The Concept of Prodromal Parkinson's Disease.帕金森病前驱期的概念。
J Parkinsons Dis. 2015;5(4):681-97. doi: 10.3233/JPD-150685.
8
Advances in markers of prodromal Parkinson disease.前驱期帕金森病标志物的研究进展。
Nat Rev Neurol. 2016 Oct 27;12(11):622-634. doi: 10.1038/nrneurol.2016.152.
9
Intraindividual Variability of Nonmotor Fluctuations in Advanced Parkinson's Disease.晚期帕金森病非运动波动的个体内变异性。
J Parkinsons Dis. 2015;5(4):737-41. doi: 10.3233/JPD-150656.
10
The prodromal phase of leucine-rich repeat kinase 2-associated Parkinson disease: Clinical and imaging Studies.富含亮氨酸重复激酶2相关帕金森病的前驱期:临床与影像学研究
Mov Disord. 2017 May;32(5):726-738. doi: 10.1002/mds.26964. Epub 2017 Mar 28.

引用本文的文献

1
Speech Characteristics Across Motor Subtypes of Parkinson's Disease.帕金森病运动亚型的言语特征
Int J Lang Commun Disord. 2025 Jul-Aug;60(4):e70081. doi: 10.1111/1460-6984.70081.
2
Retinal Thickness in Patients with Parkinson's Disease and Dopa Responsive Dystonia-Is There Any Difference?帕金森病和多巴反应性肌张力障碍患者的视网膜厚度——有差异吗?
Biomedicines. 2025 May 19;13(5):1227. doi: 10.3390/biomedicines13051227.
3
Multi-omics characterization of improved cognitive functions in Parkinson's disease patients after the combined metabolic activator treatment: a randomized, double-blinded, placebo-controlled phase II trial.

本文引用的文献

1
MDS research criteria for prodromal Parkinson's disease.前驱期帕金森病的MDS研究标准。
Mov Disord. 2015 Oct;30(12):1600-11. doi: 10.1002/mds.26431.
2
MDS clinical diagnostic criteria for Parkinson's disease.帕金森病的MDS临床诊断标准。
Mov Disord. 2015 Oct;30(12):1591-601. doi: 10.1002/mds.26424.
3
Non motor subtypes and Parkinson's disease.非运动亚型与帕金森病。
帕金森病患者联合代谢激活剂治疗后认知功能改善的多组学特征:一项随机、双盲、安慰剂对照的II期试验。
Brain Commun. 2025 Jan 6;7(1):fcae478. doi: 10.1093/braincomms/fcae478. eCollection 2025.
4
Identifying potential repurposable medications for Parkinson's disease through Mendelian randomization analysis.通过孟德尔随机化分析鉴定帕金森病的潜在可再利用药物。
Sci Rep. 2024 Aug 24;14(1):19670. doi: 10.1038/s41598-024-70758-z.
5
The Parkinson's Story of a Neurologist with 32 Years of Experience on Parkinson's Disease.一位有着32年帕金森病治疗经验的神经科医生的帕金森故事。
Noro Psikiyatr Ars. 2024 May 27;61(2):175-179. doi: 10.29399/npa.28634. eCollection 2024.
6
Can detection and prediction models for Alzheimer's Disease be applied to Prodromal Parkinson's Disease using explainable artificial intelligence? A brief report on Digital Neuro Signatures.阿尔茨海默病的检测和预测模型能否通过可解释人工智能应用于帕金森病前驱期?关于数字神经特征的简要报告。
Open Res Eur. 2022 Jan 10;1:146. doi: 10.12688/openreseurope.14216.2. eCollection 2021.
7
A review of the neurotransmitter system associated with cognitive function of the cerebellum in Parkinson's disease.帕金森病中小脑认知功能相关神经递质系统综述。
Neural Regen Res. 2024 Feb;19(2):324-330. doi: 10.4103/1673-5374.379042.
8
Neurotrophin mimetics and tropomyosin kinase receptors: a futuristic pharmacological tool for Parkinson's.神经营养因子模拟物和原肌球蛋白激酶受体:治疗帕金森病的未来药物靶点。
Neurol Sci. 2023 Jul;44(7):2265-2275. doi: 10.1007/s10072-023-06684-1. Epub 2023 Mar 4.
9
The Interrelated Multifactorial Actions of Cortisol and Klotho: Potential Implications in the Pathogenesis of Parkinson's Disease.皮质醇与klotho的相互关联的多因素作用:对帕金森病发病机制的潜在影响
Brain Sci. 2022 Dec 10;12(12):1695. doi: 10.3390/brainsci12121695.
10
Effect of acupuncture for non-motor symptoms in patients with Parkinson's disease: A systematic review and meta-analysis.针刺对帕金森病患者非运动症状的影响:一项系统评价和荟萃分析。
Front Aging Neurosci. 2022 Oct 6;14:995850. doi: 10.3389/fnagi.2022.995850. eCollection 2022.
Parkinsonism Relat Disord. 2016 Jan;22 Suppl 1:S41-6. doi: 10.1016/j.parkreldis.2015.09.027. Epub 2015 Sep 11.
4
Prediagnostic presentations of Parkinson's disease in primary care: a case-control study.帕金森病在初级保健中的预测表现:病例对照研究。
Lancet Neurol. 2015 Jan;14(1):57-64. doi: 10.1016/S1474-4422(14)70287-X. Epub 2014 Nov 27.
5
Meta-analysis of early nonmotor features and risk factors for Parkinson disease.帕金森病早期非运动特征及危险因素的荟萃分析。
Ann Neurol. 2012 Dec;72(6):893-901. doi: 10.1002/ana.23687. Epub 2012 Oct 15.
6
Imaging amyloid deposition in Lewy body diseases.路易体病中淀粉样蛋白沉积的成像
Neurology. 2008 Sep 16;71(12):903-10. doi: 10.1212/01.wnl.0000326146.60732.d6.
7
The prodromal phase of sporadic Parkinson's disease: does it exist and if so how long is it?散发性帕金森病的前驱期:它是否存在?如果存在,有多长时间?
Mov Disord. 2008 Oct 15;23(13):1799-807. doi: 10.1002/mds.22242.
8
Non-motor symptoms of Parkinson's disease: diagnosis and management.帕金森病的非运动症状:诊断与管理
Lancet Neurol. 2006 Mar;5(3):235-45. doi: 10.1016/S1474-4422(06)70373-8.
9
Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases.特发性帕金森病临床诊断的准确性:100例临床病理研究
J Neurol Neurosurg Psychiatry. 1992 Mar;55(3):181-4. doi: 10.1136/jnnp.55.3.181.