[ZEB2和C-myc在上皮性卵巢癌中的表达及其临床意义]

[Expressions of ZEB2 and C-myc in epithelial ovarian cancer and their clinical significance].

作者信息

Wang Qinghai, Jiang Huiping, Deng XiaoJie, Fang Weiyi, Guo Suiqun

机构信息

Department of Obstetrics and Gynecology, Third Affiliated Hospital1, Cancer Research Institute2, Southern Medical University, Guangzhou 510515, China. E-mail:

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2015 Dec;35(12):1765-9.

PMID:26714913

Abstract

OBJECTIVE

To investigate the expression patterns of ZEB2 and C-myc in epithelial ovarian cancer (EOC) and the associations between their expressions and the pathological features of EOC.

METHODS

The expressions of ZEB2 and C-myc proteins were detected immunohistochemically in 191 cervical cancer tissues and 13 normal ovarian tissues. The relationship between ZEB2 and C-myc protein expressions and the clinicopathological features of EOC was evaluated.

RESULTS

ZEB2 positive expression ratea in EOC tissues and normal ovarian tissues were 49.2% (94/191) and 30.8% (4/13), respectively (P=0.007), and C-myc positive expression rates in the two tissues were 53.9% (103/191) and 15.4% (2/13), respectively (P=0.001). A high expression of ZEB2 was positively correlated with the pathological type of the tumor (P=0.003), FIGO stage (P=0.028), T stage (P=0.002), and N stage (P=0.04), and a high expression of C-myc was positively correlated with FIGO stage (P=0.035), histological grade (P=0.039), and T stage (P=0.002). C-myc and ZEB2 expressions were positively correlated in EOC (P<0.001), and their co-expression in EOC was significantly correlated with T stage (R=0.358, P<0.001) and FIGO stage (P=0.008).

CONCLUSION

ZEB2 and C-myc can promote the progression, invasion and metastasis of EOC, and their combined detection may assist in early diagnosis of EOC.

摘要

目的

探讨ZEB2和C-myc在上皮性卵巢癌（EOC）中的表达模式及其表达与EOC病理特征之间的关系。

方法

采用免疫组织化学法检测191例宫颈癌组织和13例正常卵巢组织中ZEB2和C-myc蛋白的表达。评估ZEB2和C-myc蛋白表达与EOC临床病理特征的关系。

结果

EOC组织和正常卵巢组织中ZEB2阳性表达率分别为49.2%（94/191）和30.8%（4/13）（P=0.007），两种组织中C-myc阳性表达率分别为53.9%（103/191）和15.4%（2/13）（P=0.001）。ZEB2高表达与肿瘤病理类型（P=0.003）、国际妇产科联盟（FIGO）分期（P=0.028）、T分期（P=0.002）和N分期（P=0.04）呈正相关，C-myc高表达与FIGO分期（P=0.035）、组织学分级（P=0.039）和T分期（P=0.002）呈正相关。EOC中C-myc和ZEB2表达呈正相关（P<0.001），它们在EOC中的共表达与T分期（R=0.358，P<0.001）和FIGO分期（P=0.008）显著相关。