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乳糖不耐受

Lactose intolerance.

作者信息

Vandenplas Yvan

机构信息

Department of Pediatric Gastroenterology, Universitair Ziekenhuis Brussel, Brussels, Belgium. Email:

出版信息

Asia Pac J Clin Nutr. 2015;24 Suppl 1:S9-13. doi: 10.6133/apjcn.2015.24.s1.02.

Abstract

Lactose is the main carbohydrate in infant feeding, but its impact decreases as the child gets older and consumes less milk and dairy products. Congenital lactose intolerance is a very rare condition. However, lactase activity may be low and need to mature during the first weeks of life in many infants. However, the evidence that unabsorbed lactose is causing infantile crying and colic is contradictory. Unabsorbed lactose has a bifidogenic effect and improves calcium absorption. Lactose malabsorption may occur secondary and thus temporally to other etiologies such as infectious gastroenteritis, cow's milk allergy and celiac disease. One the cause is treated, lactase activity will gradually return to normal. The vast majority of Asian children will develop late onset congenital lactase deficiency. However, this entity only exceptionally causes symptoms before the age of 4-5 years. Symptoms are abdominal cramps, flatulence and watery, acid stools, and decrease the quality of life but lactose intolerance is not associated with "true disease". The diagnosis is made on clinical grounds and confirmed with a lactose breath test, if needed. These patients need to have a lifetime long reduced lactose intake to improve their quality of life.

摘要

乳糖是婴儿喂养中的主要碳水化合物,但随着孩子年龄增长,牛奶和奶制品摄入量减少,其影响也会降低。先天性乳糖不耐受是一种非常罕见的病症。然而,许多婴儿在出生后的头几周乳糖酶活性可能较低,需要逐渐成熟。不过,关于未吸收的乳糖会导致婴儿哭闹和腹绞痛的证据并不一致。未吸收的乳糖具有双歧杆菌促生长作用,并能改善钙的吸收。乳糖吸收不良可能继发于其他病因,如感染性肠胃炎、牛奶过敏和乳糜泻,且具有时间上的关联性。一旦病因得到治疗,乳糖酶活性会逐渐恢复正常。绝大多数亚洲儿童会出现迟发性先天性乳糖酶缺乏。然而,这种情况只有在极少数情况下会在4至5岁之前引发症状。症状包括腹部绞痛、肠胃胀气以及水样酸便,会降低生活质量,但乳糖不耐受与“真正的疾病”并无关联。诊断基于临床症状,如有必要,可通过乳糖呼气试验进行确诊。这些患者需要终生减少乳糖摄入量,以提高生活质量。

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