Reynolds Gretchen O, Otto Michael W, Ellis Terry D, Cronin-Golomb Alice
Boston University, Department of Psychological and Brain Sciences, Boston, Massachusetts, USA.
Boston University, College of Health and Rehabilitation Sciences: Sargent College, Department of Physical Therapy & Athletic Training and Center for Neurorehabilitation, Boston, Massachusetts, USA.
Mov Disord. 2016 Jan;31(1):23-38. doi: 10.1002/mds.26484. Epub 2015 Dec 30.
In addition to the classic motor symptoms, Parkinson's disease (PD) is associated with a variety of nonmotor symptoms that significantly reduce quality of life, even in the early stages of the disease. There is an urgent need to develop evidence-based treatments for these symptoms, which include mood disturbances, cognitive dysfunction, and sleep disruption. We focus here on exercise interventions, which have been used to improve mood, cognition, and sleep in healthy older adults and clinical populations, but to date have primarily targeted motor symptoms in PD. We synthesize the existing literature on the benefits of aerobic exercise and strength training on mood, sleep, and cognition as demonstrated in healthy older adults and adults with PD, and suggest that these types of exercise offer a feasible and promising adjunct treatment for mood, cognition, and sleep difficulties in PD. Across stages of the disease, exercise interventions represent a treatment strategy with the unique ability to improve a range of nonmotor symptoms while also alleviating the classic motor symptoms of the disease. Future research in PD should include nonmotor outcomes in exercise trials with the goal of developing evidence-based exercise interventions as a safe, broad-spectrum treatment approach to improve mood, cognition, and sleep for individuals with PD.
除了典型的运动症状外，帕金森病（PD）还伴有多种非运动症状，即使在疾病早期也会显著降低生活质量。迫切需要针对这些症状开发循证治疗方法，这些症状包括情绪障碍、认知功能障碍和睡眠紊乱。我们在此聚焦于运动干预，运动干预已被用于改善健康老年人和临床人群的情绪、认知和睡眠，但迄今为止主要针对帕金森病的运动症状。我们综合了关于有氧运动和力量训练对健康老年人及帕金森病患者的情绪、睡眠和认知有益影响的现有文献，并表明这些运动类型为帕金森病患者的情绪、认知和睡眠障碍提供了一种可行且有前景的辅助治疗方法。在疾病的各个阶段，运动干预都是一种治疗策略，具有独特的能力，既能改善一系列非运动症状，又能缓解该疾病的典型运动症状。帕金森病的未来研究应在运动试验中纳入非运动结果，目标是开发循证运动干预措施，作为一种安全、广谱的治疗方法，以改善帕金森病患者的情绪、认知和睡眠。
