Vohra Jyotsna, Marmot Michael G, Bauld Linda, Hiatt Robert A
Department of Cancer Prevention, Cancer Research UK, London, UK.
Department of Epidemiology and Public Health, UCL Institute of Health Equity, London, UK.
J Epidemiol Community Health. 2016 Jun;70(6):629-34. doi: 10.1136/jech-2015-206274. Epub 2015 Dec 29.
The relationship of childhood socioeconomic position (SEP) to adult cancer has been inconsistent in the literature and there has been no review summarising the current evidence focused solely on cancer outcomes.
We performed a rapid review of the literature, which identified 22 publications from 13 studies, primarily in the UK and northern European countries that specifically analysed individual measures of SEP in childhood and cancer outcomes in adulthood. Most of these studies adjusted for adult SEP as a critical mediator of the relationship of interest.
Results confirm that childhood socioeconomic circumstances have a strong influence on stomach cancer and are likely to contribute, along with adult circumstances, to lung cancer through cumulative exposure to smoking. There was also some evidence of increased risk of colorectal, liver, cervical and pancreatic cancers with lower childhood SEP in large studies, but small numbers of cancer deaths made these estimates imprecise. Gaps in knowledge and potential policy implications are presented.
儿童社会经济地位（SEP）与成人癌症之间的关系在文献中并不一致，且尚无综述专门总结当前仅关注癌症结局的证据。
我们对文献进行了快速综述，从13项研究中识别出22篇出版物，这些研究主要来自英国和北欧国家，专门分析了儿童期SEP的个体测量指标与成人期癌症结局。这些研究大多将成人SEP作为感兴趣关系的关键中介因素进行了调整。
结果证实，儿童期社会经济状况对胃癌有强烈影响，并且可能与成人期状况一起，通过长期吸烟暴露对肺癌产生影响。在大型研究中也有一些证据表明，儿童期SEP较低会增加结直肠癌、肝癌、宫颈癌和胰腺癌的发病风险，但癌症死亡病例数较少使得这些估计不够精确。本文还介绍了知识空白和潜在的政策影响。
