Bonasia Davide Edoardo, Marmotti Antongiulio, Rosso Federica, Collo Gianluca, Rossi Roberto
Davide Edoardo Bonasia, Antongiulio Marmotti, Federica Rosso, Gianluca Collo, Roberto Rossi, Department of Orthopaedics and Traumatology, University of Torino, AO Mauriziano "Umberto I" Hospital, 10128 Torino, Italy.
World J Orthop. 2015 Dec 18;6(11):1006-11. doi: 10.5312/wjo.v6.i11.1006.
To investigate the state of the art regarding Cartilage Autograft Implantation System (CAIS) or Particulated Juvenile Allograft Cartilage (PJAC).
The authors searched the English literature regarding CAIS and PJAC. The search strategy was: (particulated cartilage) OR autologous cartilage fragments. All basic science articles were included. Clinical articles with less than 10 patients treated and less than 6 mo of follow-up were excluded. With these criteria, a total of 17 articles were available for the present review.
PJAC and CAIS are relatively novel techniques for cartilage repair. Good basic science evidence was described to support the concept. Although the preliminary clinical reports show encouraging results, clinical data are still limited, especially for CAIS. The indications for both techniques need to be precisely defined (age of the patients, size of the lesion, and involvement of the subchondral bone), together with other debated issues.
In conclusion, the authors can state that encouraging preliminary results are available for both techniques. However, further studies are necessary to precisely determine the indications, surgical techniques, and long term outcomes for PJAC and CAIS.
探讨自体软骨移植植入系统（CAIS）或颗粒状青少年同种异体软骨（PJAC）的最新研究状况。
作者检索了关于CAIS和PJAC的英文文献。检索策略为：（颗粒状软骨）或自体软骨碎片。纳入所有基础科学文章。排除治疗患者少于10例且随访时间少于6个月的临床文章。按照这些标准，本综述共纳入17篇文章。
PJAC和CAIS是相对较新的软骨修复技术。有良好的基础科学证据支持这一概念。尽管初步临床报告显示出令人鼓舞的结果，但临床数据仍然有限，尤其是CAIS。这两种技术的适应证（患者年龄、病变大小和软骨下骨受累情况）以及其他有争议的问题都需要精确界定。
总之，作者可以指出这两种技术都有令人鼓舞的初步结果。然而，需要进一步研究以精确确定PJAC和CAIS的适应证、手术技术及长期疗效。
