Avram Annalina, Duarte Cátia, Santos Maria José, Papagoras Charalampos, Ritis Konstantinos, Scarpioni Roberto, Schmidt Wolfgang A, Skendros Panagiotis
Medical Doctor; Immanuel Krankenhaus Berlin, Medical Centre for Rheumatology Berlin - Buch, Berlin, Germany.
Rheumatologist, Rheumatology Department, Centro Hospitalar, Universitario de Coimbra, Coimbra, Portugal.
Joint Bone Spine. 2015 Oct;82 Suppl 1:eS17-29. doi: 10.1016/S1297-319X(15)30004-X.
A subgroup of patients with gouty arthritis have a chronic recurring form that is particularly difficult to treat. Such patients experience repeated flares and often have abundant tophi. Many also have underlying comorbidities, such as renal impairment, cardiovascular disease, gastrointestinal disorders, obesity, and hypertension, which contraindicate the use of standard anti-inflammatory medications. Five patients with difficult to treat gouty arthritis who were either candidates and/or treated with anti-IL therapy are described.
痛风性关节炎患者的一个亚组患有慢性复发性形式，这种形式特别难以治疗。这类患者经历反复发作，且常常有大量痛风石。许多患者还伴有潜在的合并症，如肾功能损害、心血管疾病、胃肠道疾病、肥胖症和高血压，这些情况都禁忌使用标准的抗炎药物。本文描述了5例难治性痛风性关节炎患者，他们要么是抗白细胞介素治疗的候选者，要么接受了抗白细胞介素治疗。
