Đorđević Ivana Okić, Kukolj Tamara, Krstić Jelena, Trivanović Drenka, Obradović Hristina, Santibañez Juan F, Mojsilović Slavko, Ilić Vesna, Bugarski Diana, Jauković Aleksandra
Laboratory for Experimental Hematology and Stem Cells, Institute for Medical Research, University of Belgrade, Dr Subotića 4, 11129 Belgrade, Serbia.
Laboratory for Experimental Hematology and Stem Cells, Institute for Medical Research, University of Belgrade, Dr Subotića 4, 11129 Belgrade, Serbia.
Int J Biochem Cell Biol. 2016 Feb;71:92-101. doi: 10.1016/j.biocel.2015.12.007. Epub 2015 Dec 21.
Periodontal disease (PD), a degenerative bacterially induced disease of periodontium, can lead to bone resorption and teeth loss. Development of PD includes a strong inflammatory reaction, which involves multiple immune cells and their secreting factors including interleukin-17 (IL-17), which is not only an important modulator of immune and hematopoietic responses but also affects bone metabolism. In the present study we aimed to determine whether IL-17 affects the regenerative potential of periodontal ligament mesenchymal stem cells (PDLSCs) by investigating its ability to modulate osteogenic differentiation of these cells in vitro along with associated signaling pathways. Our results revealed that IL-17 inhibited both the proliferation and migration of PDLSCs and decreased their osteogenic differentiation by activating ERK1,2 and JNK mitogen-activated protein kinases. Obtained data suggested that IL-17 might contribute to alveolar bone loss in PD.
牙周病（PD）是一种由细菌引起的牙周组织退行性疾病，可导致骨质吸收和牙齿脱落。牙周病的发展包括强烈的炎症反应，这涉及多种免疫细胞及其分泌因子，包括白细胞介素-17（IL-17），它不仅是免疫和造血反应的重要调节因子，还影响骨代谢。在本研究中，我们旨在通过研究IL-17在体外调节这些细胞成骨分化的能力以及相关信号通路，来确定IL-17是否影响牙周膜间充质干细胞（PDLSCs）的再生潜能。我们的结果显示，IL-17通过激活ERK1,2和JNK丝裂原活化蛋白激酶，抑制了PDLSCs的增殖和迁移，并降低了它们的成骨分化。获得的数据表明，IL-17可能导致牙周病中的牙槽骨丧失。
