Centro de Investigaciones Básicas y Aplicadas (CIBA), CIT NOBA, Universidad Nacional del Noroeste de la Pcia. de Bs. As. Consejo Nacional de Investigaciones Científicas y Técnicas (UNNOBA-CONICET) , Junín, Pcia. Bs. As., Argentina ; Laboratory of Tumour Microenvironment, CIBA , Junín, Pcia. Bs. As., Argentina.
Centro de Investigaciones Básicas y Aplicadas (CIBA), CIT NOBA, Universidad Nacional del Noroeste de la Pcia. de Bs. As. Consejo Nacional de Investigaciones Científicas y Técnicas (UNNOBA-CONICET) , Junín, Pcia. Bs. As., Argentina ; Laboratory of Pituitary Physiopathology, CIBA , Junín, Provincia de Buenos Aires, Argentina.
Clin Transl Immunology. 2015 Dec 4;4(12):e52. doi: 10.1038/cti.2015.35. eCollection 2015 Dec.
The relationship between the immune system and angiogenesis has been described in several contexts, both in physiological and pathological conditions, as pregnancy and cancer. In fact, different types of immune cells, such as myeloid, macrophages and denditric cells, are able to modulate tumor neovascularization. On the other hand, tumor microenvironment also includes extracellular matrix components like hyaluronan, which has a deregulated synthesis in different tumors. Hyaluronan is a glycosaminoglycan, normally present in the extracellular matrix of tissues in continuous remodeling (embryogenesis or wound healing processes) and acts as an important modulator of cell behavior by different mechanisms, including angiogenesis. In this review, we discuss hyaluronan as a modulator of tumor angiogenesis, focusing in intracellular signaling mediated by its receptors expressed on different immune cells. Recent observations suggest that the immune system is an important component in tumoural angiogenesis. Therefore, immune modulation could have an impact in anti-angiogenic therapy as a new therapeutic strategy, which in turn might improve effectiveness of treatment in cancer patients.
免疫系统和血管生成之间的关系在多种情况下都有描述，包括生理和病理条件，如妊娠和癌症。事实上，不同类型的免疫细胞，如髓样细胞、巨噬细胞和树突状细胞，能够调节肿瘤新生血管生成。另一方面，肿瘤微环境还包括细胞外基质成分，如透明质酸，在不同的肿瘤中其合成失调。透明质酸是一种糖胺聚糖，通常存在于组织的细胞外基质中，在不断重塑的过程中（胚胎发生或伤口愈合过程），并通过不同的机制（包括血管生成）作为细胞行为的重要调节剂。在这篇综述中，我们讨论了透明质酸作为肿瘤血管生成的调节剂，重点是其在不同免疫细胞上表达的受体介导的细胞内信号转导。最近的观察结果表明，免疫系统是肿瘤血管生成的一个重要组成部分。因此，免疫调节可能会对抗血管生成治疗产生影响，作为一种新的治疗策略，这反过来可能会提高癌症患者的治疗效果。
