Logan W W, Hoffman N Y
Breast Clinic of Rochester, NY 14620.
Radiology. 1989 Sep;172(3):667-70. doi: 10.1148/radiology.172.3.2672091.
Women with long-standing insulin-dependent diabetes mellitus (IDDM) and radiographically dense mammary glandular tissue can have benign breast masses clinically resembling cancer. The authors have identified 36 patients, aged 20-54 years, with this little-known condition, which the authors call diabetic fibrous breast disease (DFBD). For a diagnosis of DFBD, the patient must fulfill certain stringent requirements: a long-term history of IDDM; radiographically dense glandular tissue; and one or more hard, irregular, easily movable, discrete, painless, palpable breast masses with strong ultrasonographic acoustical shadowing and firm resistance to the back-and-forth motion of the needle used for fine-needle aspiration cytology (FNAC). Patients meeting all criteria can be monitored with serial FNAC procedures to prevent them from undergoing multiple surgical biopsies. During an average of 6 years of monitoring these 36 women, breast cancer did not develop in any mass fulfilling all requirements for DFBD.
患有长期胰岛素依赖型糖尿病（IDDM）且乳腺腺体组织在影像学上表现致密的女性，可能会出现临床上类似于癌症的良性乳腺肿块。作者已识别出36例年龄在20至54岁之间患有这种鲜为人知病症的患者，作者将其称为糖尿病性纤维性乳腺病（DFBD）。对于DFBD的诊断，患者必须满足某些严格要求：长期IDDM病史；影像学上致密的腺体组织；以及一个或多个坚硬、不规则、易于移动、离散、无痛、可触及的乳腺肿块，具有强烈的超声声影，并且对用于细针穿刺细胞学检查（FNAC）的针的来回移动具有坚实的抵抗力。符合所有标准的患者可以通过连续的FNAC程序进行监测，以防止他们接受多次手术活检。在对这36名女性平均6年的监测期间，满足DFBD所有要求的任何肿块均未发展为乳腺癌。
