Hua Hai-Bing, Yan Ting-Ting, Sun Qing-Min
Hai-Bing Hua, Department of Gastroenterology, Jiangyin Hospital Affiliated to Nanjing University of Traditional Chinese Medicine, Jiangyin 214400, Jiangsu Province, China.
World J Gastroenterol. 2014 May 21;20(19):5700-7. doi: 10.3748/wjg.v20.i19.5700.
miRNAs are endogenous 19- to 25-nt noncoding RNAs that can negatively regulate gene expression by directly cleaving target mRNA or by inhibiting its translation. Recent studies have revealed that miRNA plays a significant role in gastric cancer development either as a tumor suppressor gene or oncogene. miRNA-single-nucleotide polymorphisms (SNPs), as a novel class of functional SNPs/polymorphisms, have been identified as candidate biomarkers for gastric cancer susceptibility. On the basis of recent data, the present review summarizes current knowledge of the functional effects of miRNA-SNPs and their importance as candidate gastric cancer biomarkers. Additionally, this review also includes a meta-analysis of the most frequently studied miRNA-SNPs in gastric cancer.
微小RNA（miRNA）是内源性的19至25个核苷酸的非编码RNA，可通过直接切割靶mRNA或抑制其翻译来负调控基因表达。最近的研究表明，miRNA作为抑癌基因或癌基因在胃癌发生中起重要作用。微小RNA单核苷酸多态性（miRNA-SNP）作为一类新型的功能性单核苷酸多态性/多态性，已被确定为胃癌易感性的候选生物标志物。基于最近的数据，本综述总结了miRNA-SNP功能效应的当前知识及其作为候选胃癌生物标志物的重要性。此外，本综述还包括对胃癌中研究最频繁的miRNA-SNP的荟萃分析。
