Bahrami Afsane, Avan Amir, Sadeghnia Hamid Reza, Esmaeili Habibollah, Tayefi Maryam, Ghasemi Faezeh, Nejati Salehkhani Fatemeh, Arabpour-Dahoue Mahla, Rastgar-Moghadam Azam, Ferns Gordon A, Bahrami-Taghanaki Hamidreza, Ghayour-Mobarhan Majid
a Student Research Committee , Mashhad University of Medical Sciences , Mashhad , Iran.
b Department of Modern Sciences and Technologies, Faculty of Medicine , Mashhad University of Medical Sciences , Mashhad , Iran.
Gynecol Endocrinol. 2018 Aug;34(8):659-663. doi: 10.1080/09513590.2017.1423466. Epub 2018 Feb 15.
Vitamin D has a crucial role in female reproduction, possibly through its effects on calcium homeostasis, cyclic sex steroid hormone fluctuations, or neurotransmitter function. We have assessed the effects of vitamin D supplementation on dysmenorrhea and premenstrual syndrome (PMS) in adolescents. In this study, 897 adolescent girls living in Mashhad and Sabzevar, Iran, received nine high-dose vitamin D supplements (as 50,000 IU/week of cholecalciferol) and were followed up over 9 weeks. We evaluated the effect of vitamin D supplementation on individuals in four categories: those with only PMS; individuals with only dysmenorrhea; subjects with both PMS and dysmenorrhea and normal subjects. The prevalence of PMS after the intervention fell from 14.9% to 4.8% (p < .001). Similar results were also found for the prevalence of subjects with dysmenorrhea (35.9% reduced to 32.4%), and in subjects with both PMS and dysmenorrhea (32.7% reduced 25.7%). Vitamin D supplementation was associated with a reduction in the incidence of several symptoms of PMS such as backache and tendency to cry easily as well as decrement in pain severity of dysmenorrhea (p < .05). High dose vitamin D supplementation can reduce the prevalence of PMS and dysmenorrhea as well as has positive effects on the physical and psychological symptoms of PMS.
维生素D在女性生殖过程中起着至关重要的作用，可能是通过其对钙稳态、周期性性类固醇激素波动或神经递质功能的影响来实现的。我们评估了补充维生素D对青少年痛经和经前综合征（PMS）的影响。在本研究中，897名居住在伊朗马什哈德和萨卜泽瓦尔的青春期女孩接受了九次高剂量维生素D补充剂（以胆钙化醇50,000 IU/周的形式），并进行了为期9周的随访。我们评估了补充维生素D对四类人群的影响：仅患有PMS的人群；仅患有痛经的人群；同时患有PMS和痛经的人群以及正常人群。干预后PMS的患病率从14.9%降至4.8%（p < 0.001）。痛经患者的患病率也有类似结果（从35.9%降至32.4%），同时患有PMS和痛经的患者也是如此（从32.7%降至25.7%）。补充维生素D与PMS的几种症状发生率降低有关，如背痛和容易哭泣的倾向，以及痛经疼痛严重程度的降低（p < 0.05）。高剂量补充维生素D可以降低PMS和痛经的患病率，并对PMS的身心症状产生积极影响。
