Tang Lizhi, Zhang Fang, Tong Nanwei
Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, China.
Clin Endocrinol (Oxf). 2016 Jul;85(1):46-53. doi: 10.1111/cen.13013. Epub 2016 Feb 12.
Abdominal visceral (VAT) and subcutaneous (SAT) adipose tissues contribute to obesity, but may have different cardiometabolic risk profiles. We examined and compared the associations of abdominal VAT and SAT with metabolic risk factors in a large cohort of Chinese adults.
This study was based on cross-sectional analysis of data from 1449 adults aged 40-65 years. VAT and SAT were assessed at L4-L5 level by magnetic resonance imaging. The associations of VAT and SAT with blood pressure, glucose and lipid were examined by linear regression stratified by sex and glucose tolerance status (normal glucose tolerance and prediabetes). Logistic regression was used to analyse the association of VAT and SAT with risk of hypertension, prediabetes and dyslipidaemia.
VAT was more strongly associated with metabolic risk factors. Higher VAT was associated with higher blood pressure (βmen = 3·99, P = 0·0002; βwomen = 6·46, P = 0·0002), higher triglyceride (βmen = 0·45, P < 0·0001; βwomen = 0·6, P < 0·0001), higher total cholesterol (βmen = 0·15, P = 0·02; βwomen = 0·37, P = 0·0002) and higher 2-h glucose levels (βmen = 0·68, P = 0·003; βwomen = 0·94, P < 0·0001). The association remained significant after subjects were stratified by glucose tolerance status. However, SAT was not associated with any additional risk factors. VAT was associated with increased risk of hypertension (OR = 1·97, P < 0·0001), prediabetes (OR = 1·53, P = 0·0007) and dyslipidaemia (OR = 2·40, P < 0·0001). These associations were not observed for SAT.
VAT was more strongly associated with cardiometabolic risk factors than SAT in a large cohort of Chinese adults. Higher VAT was associated with increased risk of hypertension, dyslipidaemia and prediabetes.
腹部内脏脂肪（VAT）和皮下脂肪（SAT）与肥胖相关，但可能具有不同的心脏代谢风险特征。我们在一大群中国成年人中研究并比较了腹部VAT和SAT与代谢风险因素之间的关联。
本研究基于对1449名40 - 65岁成年人的数据进行横断面分析。通过磁共振成像在L4 - L5水平评估VAT和SAT。通过按性别和糖耐量状态（正常糖耐量和糖尿病前期）分层的线性回归研究VAT和SAT与血压、血糖和血脂的关联。采用逻辑回归分析VAT和SAT与高血压、糖尿病前期和血脂异常风险的关联。
VAT与代谢风险因素的关联更强。较高的VAT与较高的血压相关（男性β = 3.99，P = 0.0002；女性β = 6.46，P = 0.0002），较高的甘油三酯（男性β = 0.45，P < 0.0001；女性β = 0.6，P < 0.0001），较高的总胆固醇（男性β = 0.15，P = 0.02；女性β = 0.37，P = 0.0002）以及较高的2小时血糖水平（男性β = 0.68，P = 0.003；女性β = 0.94，P < 0.0001）。在按糖耐量状态对受试者进行分层后，该关联仍然显著。然而，SAT与任何额外的风险因素均无关联。VAT与高血压风险增加相关（OR = 1.97，P < 0.0001）、糖尿病前期（OR = 1.53，P = 0.0007）和血脂异常（OR = 2.40，P < 0.0001）。这些关联在SAT中未观察到。结论：在一大群中国成年人中，VAT与心脏代谢风险因素的关联比SAT更强。较高的VAT与高血压、血脂异常和糖尿病前期风险增加相关。
