Coquart Nolwenn, Cadelis Gilbert, Tressières Benoît, Cordel Nadege
Department of Dermatology, Brest University Hospital, Brest, France.
Int J Dermatol. 2015 Feb;54(2):188-92. doi: 10.1111/ijd.12633. Epub 2014 Jun 25.
There are no reliable epidemiological data on sarcoidosis in the French West Indies, although this disease is known to be more frequent and more severe in Black African-Americans and West Indians.
This retrospective study aimed to assess the incidence and prevalence of sarcoidosis in Guadeloupe over a 7-year period and to determine its epidemiological, clinical, and evolutionary characteristics.
Patients were identified through the computerized databases of the three pathology laboratories and two hospitals on the islands of Guadeloupe. Histologically proven cases of sarcoidosis were selected. All patients were recalled at a single study time-point.
A total of 75 patients were identified. These included 44 women and 31 men (sex ratio: 1.4), with a mean ± standard deviation (SD) age of 47 ± 14 years and Fitzpatrick skin types IV-VI. The average incidence was 2.28 per 100,000 inhabitants per year (95% confidence interval [CI] 1.69-3.02). The prevalence of sarcoidosis in 2009 was 21.09 per 100,000 inhabitants (95% CI 16.00-26.18). Most patients (61/71, 85.9%) exhibited multiple organ involvement; the mean ± SD number of organs involved was 2.6 ± 1.1. The initiation of systemic therapy was required in 75.7% of cases. Several lines of treatment were necessary in 41.5% of affected patients. At the study time-point, seven patients were found to have died. Four of these deaths were directly attributable to sarcoidosis (mortality rate: 5.3%).
This epidemiological study on sarcoidosis in Guadeloupe reveals a low incidence of the disease and a high degree of severity as evidenced by the average number of affected organs, the high frequency of extrathoracic organ involvement, the frequent use of corticosteroids, and a mortality rate of 5.3%.
法属西印度群岛尚无关于结节病的可靠流行病学数据，尽管已知该疾病在非洲裔美国人和西印度人中更为常见且更为严重。
这项回顾性研究旨在评估瓜德罗普岛7年间结节病的发病率和患病率，并确定其流行病学、临床和演变特征。
通过瓜德罗普岛三个病理实验室和两家医院的计算机数据库识别患者。选择经组织学证实的结节病病例。所有患者在单一研究时间点被召回。
共识别出75例患者。其中包括44名女性和31名男性（性别比：1.4），平均年龄±标准差（SD）为47±14岁，皮肤类型为菲茨帕特里克IV - VI型。年平均发病率为每10万居民2.28例（95%置信区间[CI] 1.69 - 3.02）。2009年结节病的患病率为每10万居民21.09例（95% CI 16.00 - 26.18）。大多数患者（61/71，85.9%）表现为多器官受累；受累器官的平均数量±SD为2.6±1.1。75.7%的病例需要开始全身治疗。41.5%的受影响患者需要多种治疗方案。在研究时间点，发现7例患者死亡。其中4例死亡直接归因于结节病（死亡率：5.3%）。
这项关于瓜德罗普岛结节病的流行病学研究显示，该疾病发病率较低，但严重程度较高，表现为受累器官的平均数量、胸外器官受累的高频率、皮质类固醇的频繁使用以及5.3%的死亡率。
