Ungprasert Patompong, Crowson Cynthia S, Matteson Eric L
Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, 200 First avenue SW, Rochester, MN, 55905, USA.
Division of Biomedical Statistics and Informatics, Department of Health Science Research, Mayo Clinic, Rochester, MN, 55905, USA.
Lung. 2017 Feb;195(1):87-91. doi: 10.1007/s00408-016-9952-6. Epub 2016 Oct 5.
The influence of ethnicity on epidemiology and clinical manifestations of sarcoidosis is well recognized. However, data on the role of sex are limited.
The current study utilized the resource of the Rochester Epidemiology Project to identify all residents of Olmsted County, Minnesota, United States, with new diagnosis of sarcoidosis from 1976 to 2013. Diagnosis was verified by medical record and histopathological report review.
345 incident cases of sarcoidosis were identified: 174 (50 %) were female and 171 (50 %) were male. The age at diagnosis was significantly higher among females than males (48.3 vs. 42.8 years; p < 0.001). Intra-thoracic disease was seen in the great majority of patients (98 % among females and 96 % among males; p = 0.50). However, pulmonary symptoms were significantly more frequent among males than females (51 vs. 36 %; p = 0.006). The frequency of individual extra-thoracic organ involvement was not significantly different between females and males except for cutaneous involvement and uveitis that were significantly more common among females (6 vs. 1 % for uveitis, p = 0.012 and 25 vs. 12 % for cutaneous involvement, p = 0.002). The frequency of elevate angiotensin-converting enzyme level and hypercalcemia was not significantly different between the two sexes.
Females tended to be older at the age they developed sarcoidosis, and had more uveitis and cutaneous involvement than males.
种族对结节病的流行病学和临床表现的影响已得到充分认识。然而，关于性别作用的数据有限。
本研究利用罗切斯特流行病学项目的资源，确定了1976年至2013年美国明尼苏达州奥尔姆斯特德县所有新诊断为结节病的居民。通过病历和组织病理学报告审查来核实诊断。
共确定了345例结节病新发病例：174例（50%）为女性，171例（50%）为男性。女性的诊断年龄显著高于男性（48.3岁对42.8岁；p<0.001）。绝大多数患者出现胸内疾病（女性为98%，男性为96%；p=0.50）。然而，男性出现肺部症状的频率显著高于女性（51%对36%；p=0.006）。除皮肤受累和葡萄膜炎在女性中显著更常见外（葡萄膜炎为6%对1%，p=0.012；皮肤受累为25%对12%，p=0.002），男女之间其他胸外器官受累的频率无显著差异。两性之间血管紧张素转换酶水平升高和高钙血症的频率无显著差异。
女性患结节病的年龄往往较大，且比男性有更多的葡萄膜炎和皮肤受累。
